2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-1-fluoro(diisopropyl)silyl-D-glucitol

Base Information

Chemical Name:2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-1-fluoro(diisopropyl)silyl-D-glucitol
CAS No.:222408-87-9
Molecular Formula:C₃₃H₄₃FO₄Si
Molecular Weight:550.786
Hs Code.:

Synonyms:2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-1-fluoro(diisopropyl)silyl-D-glucitol

Suppliers and Price of 2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-1-fluoro(diisopropyl)silyl-D-glucitol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-1-fluoro(diisopropyl)silyl-D-glucitol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-1-fluoro(diisopropyl)silyl-D-glucitol

There total 6 articles about 2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-1-fluoro(diisopropyl)silyl-D-glucitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 222408-86-8
2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-1-phenyl(diisopropyl)silyl-D-glucitol

: 222408-87-9
2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-1-fluoro(diisopropyl)silyl-D-glucitol

Guidance literature:: With boron trifluoride diethyl etherate; acetic acid; In dichloromethane; for 2h;
DOI:10.1080/07328309908543989

Reference yield: 14.0%

: 222408-85-7
3,4,6-tri-O-benzyl-1-deoxy-1-phenyl(diisopropyl)silyl-D-glucitol

: 222408-87-9
2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-1-fluoro(diisopropyl)silyl-D-glucitol

: 3,4,6-tri-O-benzyl-1-deoxy-1-fluoro(diisopropyl)silyl-D-glucitol

: 222408-86-8
2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-1-phenyl(diisopropyl)silyl-D-glucitol

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 20 ℃; for 1h; Yield given; Yields of byproduct given;
DOI:10.1080/07328309908543989

Reference yield:

: 96192-07-3
2,3,5-tri-O-benzyl-L-arabinofuranose

: 222408-87-9
2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-1-fluoro(diisopropyl)silyl-D-glucitol

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / tetrahydrofuran / 2 h / 60 °C

2: acetonitrile / 1 h

3: 90 percent / BF₃*Et₂O / CH₂Cl₂ / 1 h / 0 - 20 °C

4: 98 percent / BF₃*Et₂O, AcOH / CH₂Cl₂ / 2 h

With boron trifluoride diethyl etherate; acetic acid; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1080/07328309908543989