diethyl <<<3-(2,6-dimethyl-4-pyridinyl)-2,4-difluorophenyl>amino>methylene>propanedioate

Base Information

Chemical Name:diethyl <<<3-(2,6-dimethyl-4-pyridinyl)-2,4-difluorophenyl>amino>methylene>propanedioate
CAS No.:151447-07-3
Molecular Formula:C₂₁H₂₂F₂N₂O₄
Molecular Weight:404.413
Hs Code.:

Synonyms:diethyl <<<3-(2,6-dimethyl-4-pyridinyl)-2,4-difluorophenyl>amino>methylene>propanedioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl <<<3-(2,6-dimethyl-4-pyridinyl)-2,4-difluorophenyl>amino>methylene>propanedioate

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Technology Process of diethyl <<<3-(2,6-dimethyl-4-pyridinyl)-2,4-difluorophenyl>amino>methylene>propanedioate

There total 5 articles about diethyl <<<3-(2,6-dimethyl-4-pyridinyl)-2,4-difluorophenyl>amino>methylene>propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 151447-06-2
2,4-difluoro-3-(2,6-dimethyl-4-pyridinyl)benzamine

: 151447-07-3
diethyl <<<3-(2,6-dimethyl-4-pyridinyl)-2,4-difluorophenyl>amino>methylene>propanedioate

Guidance literature:: at 140 - 150 ℃; for 5h;
DOI:10.1021/jm00071a010

Reference yield:

: 64248-56-2
1-bromo-2,6-difluorobenzene

: 151447-07-3
diethyl <<<3-(2,6-dimethyl-4-pyridinyl)-2,4-difluorophenyl>amino>methylene>propanedioate

Guidance literature:: Multi-step reaction with 4 steps

1: 47 percent / PdCl₂(PPh₃)2 / dioxane; hexamethylphosphoric acid triamide / 24 h / Heating

2: 81 percent / conc. H₂SO₄, KNO₃ / 4 h / 0 - 20 °C

3: 90 percent / H₂ / PtO₂ / ethanol / 2 h

4: 89 percent / 5 h / 140 - 150 °C

With bis-triphenylphosphine-palladium(II) chloride; sulfuric acid; hydrogen; potassium nitrate; platinum(IV) oxide; In 1,4-dioxane; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol;
DOI:10.1021/jm00071a010

Reference yield:

: 81128-26-9
2,6-dimethyl-4-(trimethyl-stannyl)pyridine

: 151447-07-3
diethyl <<<3-(2,6-dimethyl-4-pyridinyl)-2,4-difluorophenyl>amino>methylene>propanedioate

Guidance literature:: Multi-step reaction with 4 steps

1: 47 percent / PdCl₂(PPh₃)2 / dioxane; hexamethylphosphoric acid triamide / 24 h / Heating

2: 81 percent / conc. H₂SO₄, KNO₃ / 4 h / 0 - 20 °C

3: 90 percent / H₂ / PtO₂ / ethanol / 2 h

4: 89 percent / 5 h / 140 - 150 °C

With bis-triphenylphosphine-palladium(II) chloride; sulfuric acid; hydrogen; potassium nitrate; platinum(IV) oxide; In 1,4-dioxane; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol;
DOI:10.1021/jm00071a010