(E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-benzyloxyphenyl}-2-methylacrylic acid

Base Information

Chemical Name:(E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-benzyloxyphenyl}-2-methylacrylic acid
CAS No.:419572-61-5
Molecular Formula:C₃₂H₃₃NO₁₁S
Molecular Weight:639.68
Hs Code.:

(E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-benzyloxyphenyl}-2-methylacrylic acid

Synonyms:(E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-benzyloxyphenyl}-2-methylacrylic acid

Suppliers and Price of (E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-benzyloxyphenyl}-2-methylacrylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-benzyloxyphenyl}-2-methylacrylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-benzyloxyphenyl}-2-methylacrylic acid

There total 6 articles about (E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-benzyloxyphenyl}-2-methylacrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 419572-65-9
(E)-3-{4-[(3aR,4S,6S,6aS)-6-(1-Benzenesulfonyl-1-nitro-ethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yloxy]-3-benzyloxy-phenyl}-2-methyl-acrylic acid ethyl ester

: 419572-61-5
(E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-benzyloxyphenyl}-2-methylacrylic acid

Guidance literature:: With sodium hydroxide; In methanol; at 50 ℃; for 16h;
DOI:10.1002/1521-3765(20020104)8:1<293::AID-CHEM293>3.0.CO;2-L

Reference yield:

: 50773-56-3
3-benzyloxy-4-hydroxybenzaldehyde

: 419572-61-5
(E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-benzyloxyphenyl}-2-methylacrylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / triisopropyl phosphite; Cs2CO3 / [η³-C3H5PdCl]2 / tetrahydrofuran / 4 h / 20 °C

2: 83 percent / N-methylmorpholine-N-oxide; aq. OsO₄ / CH₂Cl₂ / 19 h / 20 °C

3: 72 percent / CH₂Cl₂ / 16 h / 20 °C

4: 261 mg / p-TsOH / acetone / 6 h / 20 °C

5: 123 mg / aq. NaOH / methanol / 16 h / 50 °C

With sodium hydroxide; osmium(VIII) oxide; triisopropyl phosphite; caesium carbonate; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; methanol; dichloromethane; acetone; 3: Wittig reaction;
DOI:10.1002/1521-3765(20020104)8:1<293::AID-CHEM293>3.0.CO;2-L

Reference yield:

: benzoic (2SR,5SR)-5-(1-benzenesulfonyl-1-nitroethyl)-2,5-dihydrofuran-2-yl ester

: 419572-61-5
(E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-benzyloxyphenyl}-2-methylacrylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / triisopropyl phosphite; Cs2CO3 / [η³-C3H5PdCl]2 / tetrahydrofuran / 4 h / 20 °C

2: 83 percent / N-methylmorpholine-N-oxide; aq. OsO₄ / CH₂Cl₂ / 19 h / 20 °C

3: 72 percent / CH₂Cl₂ / 16 h / 20 °C

4: 261 mg / p-TsOH / acetone / 6 h / 20 °C

5: 123 mg / aq. NaOH / methanol / 16 h / 50 °C

With sodium hydroxide; osmium(VIII) oxide; triisopropyl phosphite; caesium carbonate; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; methanol; dichloromethane; acetone; 3: Wittig reaction;
DOI:10.1002/1521-3765(20020104)8:1<293::AID-CHEM293>3.0.CO;2-L