N-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-[1,1'-biphenyl]-4-carboxamide

Base Information

Chemical Name:N-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-[1,1'-biphenyl]-4-carboxamide
CAS No.:1228639-12-0
Molecular Formula:C₂₃H₂₉NO
Molecular Weight:335.489
Hs Code.:

Synonyms:N-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-[1,1'-biphenyl]-4-carboxamide

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Chemical Property of N-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-[1,1'-biphenyl]-4-carboxamide

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Technology Process of N-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-[1,1'-biphenyl]-4-carboxamide

There total 3 articles about N-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-[1,1'-biphenyl]-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 34048-57-2
(-)-(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexaneammonium chloride

: 92-92-2
biphenyl-4-carboxylic acid

: 1228639-12-0
N-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-[1,1'-biphenyl]-4-carboxamide

Guidance literature:: biphenyl-4-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.25h;

(-)-(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexaneammonium chloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2010.03.076

Reference yield: 76.0%

: 2216-54-8,787534-09-2
L-menthylamine

: 92-92-2
biphenyl-4-carboxylic acid

: 1228639-12-0
N-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-[1,1'-biphenyl]-4-carboxamide

Guidance literature:: biphenyl-4-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;

L-menthylamine; In tetrahydrofuran; at 40 ℃; for 2h;
DOI:10.1021/acsmedchemlett.1c00001

Reference yield:

: 10458-14-7,14073-97-3,17627-49-5,7786-64-3
(2R,5S)-menthone

: 1228639-12-0
N-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-[1,1'-biphenyl]-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 24 h / 20 °C

2.1: sodium; ethanol / toluene / 1.5 h / Inert atmosphere; Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / tetrahydrofuran / 1 h / 20 °C

3.2: 2 h / 40 °C

With ethanol; hydroxylamine hydrochloride; sodium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; toluene; 2.1: |Bouveault-Blanc Reduction;
DOI:10.1021/acsmedchemlett.1c00001