6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetrabenzyl ester

Base Information

Chemical Name:6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetrabenzyl ester
CAS No.:198555-76-9
Molecular Formula:C₅₃H₆₁N₅O₁₀
Molecular Weight:928.095
Hs Code.:

Synonyms:6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetrabenzyl ester

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Chemical Property of 6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetrabenzyl ester

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Technology Process of 6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetrabenzyl ester

There total 4 articles about 6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetrabenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 162898-33-1
13-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane

: 5437-45-6
Benzyl bromoacetate

: 198555-76-9
6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetrabenzyl ester

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; In tetrahydrofuran; for 6h; Heating;
DOI:10.1055/s-1997-1314

Reference yield:

: 7598-70-1
diethyl 2-(4-nitrobenzyl)malonate

: 198555-76-9
6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetrabenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / ethanol / 408 h / Heating

2: BH₃*SMe₂ / tetrahydrofuran / 24 h / Heating

3: 52 percent / aq. K₂CO₃, Bu₄NBr / tetrahydrofuran / 6 h / Heating

With dimethylsulfide borane complex; tetrabutylammomium bromide; potassium carbonate; In tetrahydrofuran; ethanol;
DOI:10.1055/s-1997-1314

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 198555-76-9
6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetrabenzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DME, 0 deg C, 0.5 h, 2.) DME, RT, 1 h

2: 41 percent / ethanol / 408 h / Heating

3: BH₃*SMe₂ / tetrahydrofuran / 24 h / Heating

4: 52 percent / aq. K₂CO₃, Bu₄NBr / tetrahydrofuran / 6 h / Heating

With dimethylsulfide borane complex; tetrabutylammomium bromide; sodium hydride; potassium carbonate; In tetrahydrofuran; ethanol;
DOI:10.1055/s-1997-1314