N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-ethyl-8-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-ethyl-8-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4-diamine
• CAS No.: 1263870-77-4
• Molecular Formula: C₂₅H₂₅ClFN₇O
• Molecular Weight: 493.971

Synonyms:N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-ethyl-8-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4-diamine

Chemical Property of N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-ethyl-8-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

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Technology Process of N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-ethyl-8-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4-diamine

There total 10 articles about N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-ethyl-8-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N4-ethyl-8-(4-fluorophenyl)-7-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4-diamine (1263870-74-1) → N2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N4-ethyl-8-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4-diamine (1263870-77-4)

Guidance literature:

N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-ethyl-8-(4-fluorophenyl)-7-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4-diamine; With trifluorormethanesulfonic acid; In toluene; for 1h; Reflux;

With sodium hydrogencarbonate; In water;

Reference yield:

ethyl 2-amino-2-(4-fluorophenyl)acetate (366018-91-9) → N2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N4-ethyl-8-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4-diamine (1263870-77-4)

Guidance literature:

Multi-step reaction with 8 steps

1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 70 °C

2: potassium carbonate / acetone / 18 h / 70 °C

3: potassium tert-butylate / tetrahydrofuran / 3 h / 20 °C

4: potassium tert-butylate / ethanol / 18 h / Reflux

5: trichlorophosphate / N,N-dimethyl-formamide / 18 h / 85 °C

6: N-ethyl-N,N-diisopropylamine / methanol / 18 h / 20 °C

7: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane; water / 24 h / 110 °C / Inert atmosphere

8: trifluorormethanesulfonic acid / toluene / 1 h / Reflux

With trifluorormethanesulfonic acid; potassium tert-butylate; sodium carbonate; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N,N-dimethyl-formamide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

(2RS)-N-(p-fluorophenyl)glycine (7292-73-1) → N2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N4-ethyl-8-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4-diamine (1263870-77-4)

Guidance literature:

Multi-step reaction with 9 steps

1: sulfuric acid / 5 h / Reflux

2: caesium carbonate / N,N-dimethyl-formamide / 18 h / 70 °C

3: potassium carbonate / acetone / 18 h / 70 °C

4: potassium tert-butylate / tetrahydrofuran / 3 h / 20 °C

5: potassium tert-butylate / ethanol / 18 h / Reflux

6: trichlorophosphate / N,N-dimethyl-formamide / 18 h / 85 °C

7: N-ethyl-N,N-diisopropylamine / methanol / 18 h / 20 °C

8: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane; water / 24 h / 110 °C / Inert atmosphere

9: trifluorormethanesulfonic acid / toluene / 1 h / Reflux

With trifluorormethanesulfonic acid; sulfuric acid; potassium tert-butylate; sodium carbonate; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N,N-dimethyl-formamide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetone; toluene;

upstream raw materials:

ethyl 2-amino-2-(4-fluorophenyl)acetate

2-chloro-5-nitroanisole

(2RS)-N-(p-fluorophenyl)glycine

4-chloro-1-(2-methoxy-4-nitrophenyl)-1H-imidazole

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