4-diazo-5-oxo-5-p-tolyl-3-trifluoromethyl-pent-2-enoic acid methyl ester

Base Information

Chemical Name:4-diazo-5-oxo-5-p-tolyl-3-trifluoromethyl-pent-2-enoic acid methyl ester
CAS No.:872186-82-8
Molecular Formula:C₁₄H₁₁F₃N₂O₃
Molecular Weight:312.248
Hs Code.:

4-diazo-5-oxo-5-<i>p</i>-tolyl-3-trifluoromethyl-pent-2-enoic acid methyl ester

Synonyms:4-diazo-5-oxo-5-p-tolyl-3-trifluoromethyl-pent-2-enoic acid methyl ester

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Chemical Property of 4-diazo-5-oxo-5-p-tolyl-3-trifluoromethyl-pent-2-enoic acid methyl ester

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Technology Process of 4-diazo-5-oxo-5-p-tolyl-3-trifluoromethyl-pent-2-enoic acid methyl ester

There total 3 articles about 4-diazo-5-oxo-5-p-tolyl-3-trifluoromethyl-pent-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 307531-57-3
2-diazo-4,4,4-trifluoro-1-p-tolyl-butane-1,3-dione

: 872186-82-8
4-diazo-5-oxo-5-p-tolyl-3-trifluoromethyl-pent-2-enoic acid methyl ester

Guidance literature:: In diethyl ether; at 20 ℃;
DOI:10.1055/s-2005-872180

Reference yield:

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 307531-57-3
2-diazo-4,4,4-trifluoro-1-p-tolyl-butane-1,3-dione

: 872186-82-8
4-diazo-5-oxo-5-p-tolyl-3-trifluoromethyl-pent-2-enoic acid methyl ester

: 791-28-6
Triphenylphosphine oxide

Guidance literature:: In diethyl ether; at 20 ℃;
DOI:10.1016/j.jfluchem.2007.01.004

Reference yield:

: 720-94-5
4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione

: 872186-82-8
4-diazo-5-oxo-5-p-tolyl-3-trifluoromethyl-pent-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / DBU; 3-nitro-4-methyl-benzenesulfonyl azide / CH₂Cl₂ / 20 °C

2: 63 percent / diethyl ether / 20 °C

With 4-methyl-3-nitrobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In diethyl ether; dichloromethane; 2: Wittig reaction;
DOI:10.1055/s-2005-872180