4-[4-(t-butyldimethylsilyloxymethyl)-2-[1-(1-naphthyl)ethylcarbonylamino]phenyl]butanoic acid methyl ester

Base Information

Chemical Name:4-[4-(t-butyldimethylsilyloxymethyl)-2-[1-(1-naphthyl)ethylcarbonylamino]phenyl]butanoic acid methyl ester
CAS No.:499157-39-0
Molecular Formula:C₃₁H₄₁NO₄Si
Molecular Weight:519.756
Hs Code.:

Synonyms:4-[4-(t-butyldimethylsilyloxymethyl)-2-[1-(1-naphthyl)ethylcarbonylamino]phenyl]butanoic acid methyl ester

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Chemical Property of 4-[4-(t-butyldimethylsilyloxymethyl)-2-[1-(1-naphthyl)ethylcarbonylamino]phenyl]butanoic acid methyl ester

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Technology Process of 4-[4-(t-butyldimethylsilyloxymethyl)-2-[1-(1-naphthyl)ethylcarbonylamino]phenyl]butanoic acid methyl ester

There total 8 articles about 4-[4-(t-butyldimethylsilyloxymethyl)-2-[1-(1-naphthyl)ethylcarbonylamino]phenyl]butanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5078-73-9
2-(1-naphthyl)propionyl chloride

: C₁₈H₃₁NO₃Si

: 499157-39-0
4-[4-(t-butyldimethylsilyloxymethyl)-2-[1-(1-naphthyl)ethylcarbonylamino]phenyl]butanoic acid methyl ester

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 499157-36-7
4-(4-hydroxymethyl-2-nitrophenyl)butanoic acid methyl ester

: 499157-39-0
4-[4-(t-butyldimethylsilyloxymethyl)-2-[1-(1-naphthyl)ethylcarbonylamino]phenyl]butanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / DMF (N,N-dimethyl-formamide) / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

3: pyridine / dichloromethane / 0.5 h / 20 °C

With pyridine; 1H-imidazole; hydrogen; palladium 10% on activated carbon; In methanol; DMF (N,N-dimethyl-formamide); dichloromethane;

Reference yield:

: 499157-32-3
tert-butyl 4-iodo-3-nitrobenzoate

: 499157-39-0
4-[4-(t-butyldimethylsilyloxymethyl)-2-[1-(1-naphthyl)ethylcarbonylamino]phenyl]butanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,1-Dibromoethane; zinc / tetrahydrofuran / 0.08 h / Heating / reflux

1.2: 0.08 h

2.1: trifluoroacetic acid / methoxybenzene / 1 h / 60 °C

3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 °C

3.2: 0.5 h / 0 °C

4.1: 1H-imidazole / DMF (N,N-dimethyl-formamide) / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

6.1: pyridine / dichloromethane / 0.5 h / 20 °C

With pyridine; 1H-imidazole; 1,1-Dibromoethane; hydrogen; chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; zinc; palladium 10% on activated carbon; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); dichloromethane; methoxybenzene;