(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-chloro-3-vinyl-1H-indazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

Base Information

Chemical Name:(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-chloro-3-vinyl-1H-indazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide
CAS No.:1375278-61-7
Molecular Formula:C₂₈H₂₅ClN₄O₄
Molecular Weight:516.984
Hs Code.:

Synonyms:(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-chloro-3-vinyl-1H-indazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

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Chemical Property of (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-chloro-3-vinyl-1H-indazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

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Technology Process of (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-chloro-3-vinyl-1H-indazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

There total 6 articles about (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-chloro-3-vinyl-1H-indazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1375278-60-6
2-(4-chloro-3-vinyl-1H-indazol-1-yl)acetic acid

: 1375278-62-8
(S)-2-amino-N-(benzo[d][1,3]dioxol-5-yl)-N-methyl-3-phenylpropanamide

: 1375278-61-7
(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-chloro-3-vinyl-1H-indazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 13096-96-3
4-chloro-1H-indazole

: 1375278-61-7
(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-chloro-3-vinyl-1H-indazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 0 - 20 °C

2.1: triethylamine / dichloromethane / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / Reflux; Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.83 h / 20 °C

4.2: 0.5 h / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 387-45-1
2-chloro-6-fluorobenzaldehyde

: 1375278-61-7
(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-chloro-3-vinyl-1H-indazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine hydrate / 1,2-dimethoxyethane / Reflux

2.1: potassium hydroxide / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 0 - 20 °C

3.1: triethylamine / dichloromethane / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / Reflux; Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.83 h / 20 °C

5.2: 0.5 h / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;