carbamic acid [(3-nitrophenyl)methyl]-(3S)-tetrahydro-3-furanyl ester

Base Information

• Chemical Name: carbamic acid [(3-nitrophenyl)methyl]-(3S)-tetrahydro-3-furanyl ester
• CAS No.: 914810-53-0
• Molecular Formula: C₁₂H₁₄N₂O₅
• Molecular Weight: 266.254
• Mol file: 914810-53-0.mol

Synonyms:carbamic acid [(3-nitrophenyl)methyl]-(3S)-tetrahydro-3-furanyl ester

Chemical Property of carbamic acid [(3-nitrophenyl)methyl]-(3S)-tetrahydro-3-furanyl ester

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of carbamic acid [(3-nitrophenyl)methyl]-(3S)-tetrahydro-3-furanyl ester

There total 1 articles about carbamic acid [(3-nitrophenyl)methyl]-(3S)-tetrahydro-3-furanyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.4%

3-nitrobenzylamine hydrochloride (26177-43-5) + (S)-tetrahydrofuran-3-yl carbonochloridate (178153-11-2) → carbamic acid [(3-nitrophenyl)methyl]-(3S)-tetrahydro-3-furanyl ester (914810-53-0)

Guidance literature:

With sodium carbonate; In water; toluene; at 20 - 50 ℃; for 1.75h;

Reference yield:

carbamic acid [(3-nitrophenyl)methyl]-(3S)-tetrahydro-3-furanyl ester (914810-53-0) → [(3-aminophenyl)methyl] carbamic acid [(3S)-tetrahydro-3-furanyl] ester (267406-34-8)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In ethyl acetate; at 20 - 25 ℃; under 1500.15 - 5063.01 Torr; Product distribution / selectivity; Parr bomb;

Reference yield:

carbamic acid [(3-nitrophenyl)methyl]-(3S)-tetrahydro-3-furanyl ester (914810-53-0) → carbamic acid [[3-[(phenoxycarbonyl)amino]phenyl]methyl]-(3S)-tetrahydro-3-furanyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; 5%-palladium/activated carbon / ethyl acetate / 7 h / 25 °C / 4500.45 Torr / Inert atmosphere; Large scale

2: water; ethyl acetate / 4.5 h / 50 °C / Inert atmosphere; Large scale

With 5%-palladium/activated carbon; hydrogen; In water; ethyl acetate;

DOI:10.1021/op800060h

upstream raw materials:

3-nitrobenzylamine hydrochloride

(S)-tetrahydrofuran-3-yl carbonochloridate

Downstream raw materials:

[(3-aminophenyl)methyl] carbamic acid [(3S)-tetrahydro-3-furanyl] ester