4-(2-(4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl)ethynyl)phenyl trans-4-propylcyclohexanecarboxylate

Base Information

Chemical Name:4-(2-(4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl)ethynyl)phenyl trans-4-propylcyclohexanecarboxylate
CAS No.:1437796-86-5
Molecular Formula:C₂₈H₂₇F₂NO₂
Molecular Weight:447.525
Hs Code.:

Synonyms:4-(2-(4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl)ethynyl)phenyl trans-4-propylcyclohexanecarboxylate

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Chemical Property of 4-(2-(4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl)ethynyl)phenyl trans-4-propylcyclohexanecarboxylate

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Technology Process of 4-(2-(4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl)ethynyl)phenyl trans-4-propylcyclohexanecarboxylate

There total 4 articles about 4-(2-(4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl)ethynyl)phenyl trans-4-propylcyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.84%

: 38289-27-9
trans-4-propyl-cyclohexanecarboxylic acid

: 1437796-91-2
4-(2-(4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl)ethynyl)phenol

: 1437796-86-5
4-(2-(4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl)ethynyl)phenyl trans-4-propylcyclohexanecarboxylate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In chloroform; at 90 ℃; for 12h;
DOI:10.1016/j.tet.2013.04.077

Reference yield:

: 1437796-88-7
3,3,4,4-tetrafluoro-1-(4-iodophenyl)pyrrolidine

: 1437796-86-5
4-(2-(4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl)ethynyl)phenyl trans-4-propylcyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium t-butanolate / dimethyl sulfoxide / 12 h / 90 °C / Inert atmosphere

2: copper(l) iodide; triphenylphosphine / water / 24 h / 120 °C / Inert atmosphere

3: sodium t-butanolate / dimethyl sulfoxide / 12 h / 90 °C

4: dmap; dicyclohexyl-carbodiimide / chloroform / 12 h / 90 °C

With dmap; copper(l) iodide; dicyclohexyl-carbodiimide; triphenylphosphine; sodium t-butanolate; In chloroform; water; dimethyl sulfoxide; 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2013.04.077

Reference yield:

: 1437796-89-8
3,4-difluoro-1-(4-iodophenyl)-1H-pyrrole

: 1437796-86-5
4-(2-(4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl)ethynyl)phenyl trans-4-propylcyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; triphenylphosphine / water / 24 h / 120 °C / Inert atmosphere

2: sodium t-butanolate / dimethyl sulfoxide / 12 h / 90 °C

3: dmap; dicyclohexyl-carbodiimide / chloroform / 12 h / 90 °C

With dmap; copper(l) iodide; dicyclohexyl-carbodiimide; triphenylphosphine; sodium t-butanolate; In chloroform; water; dimethyl sulfoxide; 1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2013.04.077