(E)-dimethyl 2-(4,4-dimethyl-1-(3-(trifluoromethyl)phenyl)pent-2-en-1-yl)malonate

Base Information

Chemical Name:(E)-dimethyl 2-(4,4-dimethyl-1-(3-(trifluoromethyl)phenyl)pent-2-en-1-yl)malonate
CAS No.:1574570-04-9
Molecular Formula:C₁₉H₂₃F₃O₄
Molecular Weight:372.384
Hs Code.:

Synonyms:(E)-dimethyl 2-(4,4-dimethyl-1-(3-(trifluoromethyl)phenyl)pent-2-en-1-yl)malonate

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Chemical Property of (E)-dimethyl 2-(4,4-dimethyl-1-(3-(trifluoromethyl)phenyl)pent-2-en-1-yl)malonate

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Technology Process of (E)-dimethyl 2-(4,4-dimethyl-1-(3-(trifluoromethyl)phenyl)pent-2-en-1-yl)malonate

There total 2 articles about (E)-dimethyl 2-(4,4-dimethyl-1-(3-(trifluoromethyl)phenyl)pent-2-en-1-yl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1574569-62-2,71058-50-9
C₆H₁₁AlCl₂

: 500000-67-9
dimethyl 2-(3-(trifluoromethyl)benzylidene)malonate

: 1574570-04-9
(E)-dimethyl 2-(4,4-dimethyl-1-(3-(trifluoromethyl)phenyl)pent-2-en-1-yl)malonate

Guidance literature:: In diethyl ether; at 0 ℃; for 2h; chemoselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.01.105

Reference yield:

: 917-92-0
3,3-Dimethylbut-1-yne

: 1574570-04-9
(E)-dimethyl 2-(4,4-dimethyl-1-(3-(trifluoromethyl)phenyl)pent-2-en-1-yl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 2 h / 70 °C / Inert atmosphere

2: diethyl ether / 2 h / 0 °C / Schlenk technique; Inert atmosphere

With bis(cyclopentadienyl)titanium dichloride; In tetrahydrofuran; diethyl ether; 2: |Michael Addition;
DOI:10.1016/j.tetlet.2014.01.105