11-<3'-(benzoyloxy)-17'-oxoestra-1',3',5'(10')-trien-7'α-yl>undecanoic acid

Base Information

• Chemical Name: 11-<3'-(benzoyloxy)-17'-oxoestra-1',3',5'(10')-trien-7'α-yl>undecanoic acid
• CAS No.: 55592-11-5
• Molecular Formula: C₃₆H₄₆O₅
• Molecular Weight: 558.758
• Mol file: 55592-11-5.mol

Synonyms:11-<3'-(benzoyloxy)-17'-oxoestra-1',3',5'(10')-trien-7'α-yl>undecanoic acid

Chemical Property of 11-<3'-(benzoyloxy)-17'-oxoestra-1',3',5'(10')-trien-7'α-yl>undecanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-<3'-(benzoyloxy)-17'-oxoestra-1',3',5'(10')-trien-7'α-yl>undecanoic acid

There total 1 articles about 11-<3'-(benzoyloxy)-17'-oxoestra-1',3',5'(10')-trien-7'α-yl>undecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-benzoyloxy 7α-(11'-hydroxy undecyl) estra-1,3,5(10)-trien-17β-ol (55592-10-4) → 11-<3'-(benzoyloxy)-17'-oxoestra-1',3',5'(10')-trien-7'α-yl>undecanoic acid (55592-11-5)

Guidance literature:

With jones reagent; In acetone; at 0 ℃; for 2h;

DOI:10.1016/S0223-5234(00)00124-0

Reference yield:

11-<3'-(benzoyloxy)-17'-oxoestra-1',3',5'(10')-trien-7'α-yl>undecanoic acid (55592-11-5) + isobutyl chloroformate (543-27-1) → Benzoic acid (7R,8R,9S,13S,14S)-7-(11-isobutoxycarbonyloxy-11-oxo-undecyl)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:

With tributyl-amine; In dichloromethane; for 0.583333h;

DOI:10.1021/jm00109a014

Reference yield:

11-<3'-(benzoyloxy)-17'-oxoestra-1',3',5'(10')-trien-7'α-yl>undecanoic acid (55592-11-5) → N-n-butyl-N-methyl-11-(3'-(benzoyloxy)-17'-oxoestra-1',3',5'(10')-trien-7'α-yl)undecanamide (131811-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Bu₃N / CH₂Cl₂ / 1.33 h / -10 °C

2: 8.83 g / CH₂Cl₂ / 2.5 h / -10 - 20 °C

With tributyl-amine; In dichloromethane; 1: Condensation / 2: Substitution;

DOI:10.1016/S0223-5234(00)00124-0

upstream raw materials:

3-benzoyloxy 7α-(11'-hydroxy undecyl) estra-1,3,5(10)-trien-17β-ol

Downstream raw materials:

N-n-butyl-N-methyl-11-(3'-(benzoyloxy)-17'-oxoestra-1',3',5'(10')-trien-7'α-yl)undecanamide

N-n-butyl-N-methyl-11-<16'β-<(p-tolylsulfonyl)oxy>-3'-acetoxy-17'-oxoestra-1',3',5'(10')-trien-7'α-yl>undecanamide

EM-139