2-(2,4-difluorophenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

Base Information

Chemical Name:2-(2,4-difluorophenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole
CAS No.:1269439-93-1
Molecular Formula:C₂₅H₂₂F₂N₆
Molecular Weight:444.487
Hs Code.:

Synonyms:2-(2,4-difluorophenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

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Chemical Property of 2-(2,4-difluorophenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

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Technology Process of 2-(2,4-difluorophenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

There total 7 articles about 2-(2,4-difluorophenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1269439-90-8
5-formyl-2-(2,4-difluorophenyl)benzimidazole

: 54998-08-2
4-(4-methylpiperazino)-1,2-diaminobenzene

: 1269439-93-1
2-(2,4-difluorophenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

Guidance literature:: With sodium metabisulfite; In ethanol; water; for 6h; Reflux;
DOI:10.1016/j.ejmech.2010.11.046

Reference yield:

: 1269439-88-4
5-cyano-2-(2,4-difluorophenyl)benzimidazole

: 1269439-93-1
2-(2,4-difluorophenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: nickel/aluminium alloy; formic acid / water / 5 h / 95 °C / Inert atmosphere

2: sodium metabisulfite / ethanol; water / 6 h / Reflux

With sodium metabisulfite; formic acid; nickel/aluminium alloy; In ethanol; water;
DOI:10.1016/j.ejmech.2010.11.046

Reference yield:

: 6393-40-4
4-Amino 3-nitro-benzonitrile

: 1269439-93-1
2-(2,4-difluorophenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 0.5 h / 20 °C / 1137.76 - 2172.08 Torr

2: sodium metabisulfite / ethanol; water / 5 h / Reflux

3: nickel/aluminium alloy; formic acid / water / 5 h / 95 °C / Inert atmosphere

4: sodium metabisulfite / ethanol; water / 6 h / Reflux

With sodium metabisulfite; formic acid; nickel/aluminium alloy; palladium 10% on activated carbon; hydrogen; In ethanol; water;
DOI:10.1016/j.ejmech.2010.11.046