Boc-Val-Tyr-OBzl

Base Information

• Chemical Name: Boc-Val-Tyr-OBzl
• CAS No.: 75957-53-8
• Molecular Formula: C26H34 N2 O6
• Molecular Weight: 470.566
• Mol file: 75957-53-8.mol

Synonyms:L-Tyrosine,N-[N-[(1,1-dimethylethoxy)carbonyl]-L-valyl]-, phenylmethyl ester;2-bromo-3-methoxy-3-methylbutanoic acid;

Chemical Property of Boc-Val-Tyr-OBzl

Chemical Property:

• Boiling Point: 259 °C at 760 mmHg
• Flash Point: 110.4 °C
• PSA: 113.96000
• Density: 1.484 g/cm³
• LogP: 4.49400

Purity/Quality:

99% ^*data from raw suppliers

BOC-VAL-TYR-OBZL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boc-Val-Tyr-OBzl

There total 5 articles about Boc-Val-Tyr-OBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

t-Boc-L-valine (13734-41-3) + L-tyrosine benzyl ester (42406-77-9) → N-[N-(tert-butoxycarbonyl)-L-valyl]-L-tyrosine benzyl ester (75957-53-8)

Guidance literature:

t-Boc-L-valine; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -10 ℃; for 0.0833333h;

L-tyrosine benzyl ester; With 4-methyl-morpholine; benzotriazol-1-ol; In tetrahydrofuran; dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/ja0256461

Reference yield: 88.0%

t-Boc-L-valine (13734-41-3) + L-tyrosine benzyl ester p-toluenesulfonate (53587-11-4,97984-63-9) → N-[N-(tert-butoxycarbonyl)-L-valyl]-L-tyrosine benzyl ester (75957-53-8)

Guidance literature:

t-Boc-L-valine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 0.5h;

L-tyrosine benzyl ester p-toluenesulfonate; With 4-methyl-morpholine; In tetrahydrofuran; at 20 ℃; for 8h; pH=9;

DOI:10.1039/c5tb01930c

Reference yield: 79.0%

t-Boc-L-valine (13734-41-3) + C21H25NO5*C7H8O3S → N-[N-(tert-butoxycarbonyl)-L-valyl]-L-tyrosine benzyl ester (75957-53-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/acs.joc.9b00970

upstream raw materials:

t-Boc-L-valine

L-tyrosine benzyl ester p-toluenesulfonate

Boc-Val-ONSu

L-tyrosine benzyl ester

Downstream raw materials:

L-valyl-L-tyrosine

H-Val-Tyr-OBzl

H-Val-Tyr-OBzl*TFA

5-bromopentanoyl-L-valinyl-L-tyrosine benzyl ester