Z-LYS(TOS)-OH

Base Information

• Chemical Name: Z-LYS(TOS)-OH
• CAS No.: 2362-45-0
• Molecular Formula: C21H26 N2 O6 S
• Molecular Weight: 434.513
• Hs Code.: 2935009090
• Mol file: 2362-45-0.mol

Synonyms:L-Lysine,N2-carboxy-N6-p-tolylsulfonyl-, N-benzyl ester (6CI); Lysine,N2-carboxy-N6-(p-tolylsulfonyl)-, N-benzyl ester (7CI); Lysine,N2-carboxy-N6-(p-tolylsulfonyl)-, N2-benzyl ester, L- (8CI)

Chemical Property of Z-LYS(TOS)-OH

Chemical Property:

• Melting Point: 102-103 °C
• PKA: 3.96±0.21(Predicted)
• PSA: 130.18000
• Density: 1.278±0.06 g/cm3(Predicted)
• LogP: 4.68580

Purity/Quality:

98% ^*data from raw suppliers

N-alpha-Z-Nε-4-toluenesulfonyl-L-lysine dicyclohexylammonium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-LYS(TOS)-OH

There total 1 articles about Z-LYS(TOS)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N2-(toluene-4-sulfonyl)-L-lysine (2104-87-2) + benzyl chloroformate (501-53-1,94274-21-2) → carbobenzyloxy-N-epsilon-tosyl-L-lysine (2362-45-0)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01603a047

Reference yield: 88.0%

carbobenzyloxy-N-epsilon-tosyl-L-lysine (2362-45-0) + H-Lys(Tos)-Tyr-OMe*HCl (92399-13-8) → Z-Lys(Tos)-Lys(Tos)-Tyr-OMe (92399-14-9)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1021/ja00337a046

Reference yield: 86.0%

carbobenzyloxy-N-epsilon-tosyl-L-lysine (2362-45-0) + L-tyrosine methyl ester HCl (3417-91-2) → Z-Lys(Tos)-Tyr-OMe (92399-12-7)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja00337a046

upstream raw materials:

N²-(toluene-4-sulfonyl)-L-lysine

benzyl chloroformate

Downstream raw materials:

N-[N²-benzyloxycarbonyl-N⁶-(toluene-4-sulfonyl)-L-lysyl]-L-aspartic acid dimethyl ester

N-[N²-benzyloxycarbonyl-N⁶-(toluene-4-sulfonyl)-L-lysyl]-glycine ethyl ester

N^ε-Tosyl-N^α-benzyloxycarbonyl-L-lysyl-L-alaninmetylester

(S)-2-[(S)-2-Benzyloxycarbonylamino-6-(toluene-4-sulfonylamino)-hexanoylamino]-3-hydroxy-propionic acid methyl ester