7-methylene-4-((4R)-4-phenyl-4,5-dihydrooxazol-2-yl)-5,6-dihydro-7H-cyclopenta[c]pyridine

Base Information

Chemical Name:7-methylene-4-((4R)-4-phenyl-4,5-dihydrooxazol-2-yl)-5,6-dihydro-7H-cyclopenta[c]pyridine
CAS No.:936831-76-4
Molecular Formula:C₁₈H₁₆N₂O
Molecular Weight:276.338
Hs Code.:

Synonyms:7-methylene-4-((4R)-4-phenyl-4,5-dihydrooxazol-2-yl)-5,6-dihydro-7H-cyclopenta[c]pyridine

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Chemical Property of 7-methylene-4-((4R)-4-phenyl-4,5-dihydrooxazol-2-yl)-5,6-dihydro-7H-cyclopenta[c]pyridine

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Technology Process of 7-methylene-4-((4R)-4-phenyl-4,5-dihydrooxazol-2-yl)-5,6-dihydro-7H-cyclopenta[c]pyridine

There total 5 articles about 7-methylene-4-((4R)-4-phenyl-4,5-dihydrooxazol-2-yl)-5,6-dihydro-7H-cyclopenta[c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 936831-73-1
3-bromo-4-(but-3-enyl)-5-((4R)-phenyloxazolin-2-yl)pyridine

: 936831-76-4
7-methylene-4-((4R)-4-phenyl-4,5-dihydrooxazol-2-yl)-5,6-dihydro-7H-cyclopenta[c]pyridine

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine; silver carbonate; palladium diacetate; In dichloromethane; at 80 ℃; for 2h;
DOI:10.1016/j.tet.2007.02.090

Reference yield:

: 936831-72-0
3-bromo-5-((4R)-phenyloxazolin-2-yl)pyridine

: 936831-76-4
7-methylene-4-((4R)-4-phenyl-4,5-dihydrooxazol-2-yl)-5,6-dihydro-7H-cyclopenta[c]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: Mg; iodine / diethyl ether / 1 h / Heating

1.2: tetrahydrofuran; diethyl ether / 1 h / 20 °C

2.1: 846 mg / O₂ / ethyl acetate / 48 h

3.1: 83 percent / dppf; triethylamine; Ag₂CO₃ / Pd(OAc)2 / CH₂Cl₂ / 2 h / 80 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; iodine; oxygen; magnesium; triethylamine; silver carbonate; palladium diacetate; In diethyl ether; dichloromethane; ethyl acetate; 3.1: Heck ring closure;
DOI:10.1016/j.tet.2007.02.090

Reference yield:

: 3-bromo-4-but-3-enyl-5-(4-phenyl-4,5-dihydro-oxazol-2-yl)-1,4-dihydro-pyridine

: 936831-76-4
7-methylene-4-((4R)-4-phenyl-4,5-dihydrooxazol-2-yl)-5,6-dihydro-7H-cyclopenta[c]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 846 mg / O₂ / ethyl acetate / 48 h

2: 83 percent / dppf; triethylamine; Ag₂CO₃ / Pd(OAc)2 / CH₂Cl₂ / 2 h / 80 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; oxygen; triethylamine; silver carbonate; palladium diacetate; In dichloromethane; ethyl acetate; 2: Heck ring closure;
DOI:10.1016/j.tet.2007.02.090