Multi-step reaction with 9 steps
1.1: hydrogen; ammonia / Raney Ni / water; methanol / 22 °C / 2585.81 Torr
2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 22 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.33 h / 0 - 22 °C
3.2: 0.5 h
4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 22 °C
5.1: hydrazine / chloroform; methanol / 0.5 h / 22 °C
6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.25 h / 22 °C
6.2: 1 h
7.1: diethylamine / trisodium tris(3-sulfophenyl)phosphine; palladium diacetate / acetonitrile; water / 1 h / 22 °C
8.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 22 °C
9.1: hydrogenchloride / 1,4-dioxane; water / 18 h / 22 °C
With
hydrogenchloride; lithium aluminium tetrahydride; ammonia; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; hydrazine; diethylazodicarboxylate;
trisodium tris(3-sulfophenyl)phosphine; palladium diacetate;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;