Nα-carbobenzoxy-Nγ-tert-butoxycarbonyl-2,4-diaminobutyrylglycine methyl ester

Base Information

Chemical Name:Nα-carbobenzoxy-Nγ-tert-butoxycarbonyl-2,4-diaminobutyrylglycine methyl ester
CAS No.:929087-74-1
Molecular Formula:C₂₀H₂₉N₃O₇
Molecular Weight:423.466
Hs Code.:

Synonyms:Nα-carbobenzoxy-Nγ-tert-butoxycarbonyl-2,4-diaminobutyrylglycine methyl ester

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Chemical Property of Nα-carbobenzoxy-Nγ-tert-butoxycarbonyl-2,4-diaminobutyrylglycine methyl ester

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Technology Process of Nα-carbobenzoxy-Nγ-tert-butoxycarbonyl-2,4-diaminobutyrylglycine methyl ester

There total 3 articles about Nα-carbobenzoxy-Nγ-tert-butoxycarbonyl-2,4-diaminobutyrylglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 49855-91-6
2--4--L-2,4-diaminobutyric acid

: 616-34-2
methoxycarbonylmethylamine

: 929087-74-1
Nα-carbobenzoxy-Nγ-tert-butoxycarbonyl-2,4-diaminobutyrylglycine methyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.bmcl.2006.10.061

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 929087-74-1
Nα-carbobenzoxy-Nγ-tert-butoxycarbonyl-2,4-diaminobutyrylglycine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 37 percent / Et₃N; aq. NaOH / methanol / 24 h / 20 °C

2: 59 percent / DIEA; TBTU / dimethylformamide / 24 h / 20 °C

With sodium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.10.061

Reference yield:

: 62234-40-6
(2S)-2-{[(benzyloxy)carbonyl]amino}-4-(dimethylamino)butanoic acid

: 929087-74-1
Nα-carbobenzoxy-Nγ-tert-butoxycarbonyl-2,4-diaminobutyrylglycine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 37 percent / Et₃N; aq. NaOH / methanol / 24 h / 20 °C

2: 59 percent / DIEA; TBTU / dimethylformamide / 24 h / 20 °C

With sodium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.10.061