D-2,4-diaminobutyric Acid Dihydrochloride

Base Information

• Chemical Name: D-2,4-diaminobutyric Acid Dihydrochloride
• CAS No.: 127531-11-7
• Molecular Formula: C₄H₁₂N₂O₂*2Cl
• Molecular Weight: 191.057
• Hs Code.: 2922499990
• Mol file: 127531-11-7.mol

Synonyms:(R)-2,4-Diaminobutanoic acid dihydrochloride;

Chemical Property of D-2,4-diaminobutyric Acid Dihydrochloride

Chemical Property:

• Vapor Pressure: 5.7E-06mmHg at 25°C
• Boiling Point: 354.2 °C at 760 mmHg
• Flash Point: 168 °C
• PSA: 89.34000
• LogP: 1.75170
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

D-2,4-DiaminobutyricAcidDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of D-2,4-diaminobutyric Acid Dihydrochloride

There total 3 articles about D-2,4-diaminobutyric Acid Dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Nα,Nγ-bis(t-butoxycarbonyl)-L-α,γ-butyric acid (34404-27-8,752986-92-8) → (S)-2,4-diaminobutyric acid dihydrochloride (1482-98-0,1883-09-6,6970-28-1,19391-83-4,26889-08-7,40149-78-8,57538-26-8,65427-54-5,66837-03-4,89700-93-6,101854-78-8,127531-11-7)

Guidance literature:

With hydrogenchloride;

DOI:10.1016/j.tetlet.2006.11.033

Reference yield:

(S)-3-Cyano-2-[(1R,2R,5R)-2-hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-propionic acid ethyl ester (127531-09-3,127531-10-6) → (S)-2,4-diaminobutyric acid dihydrochloride (1482-98-0,1883-09-6,6970-28-1,19391-83-4,26889-08-7,40149-78-8,57538-26-8,65427-54-5,66837-03-4,89700-93-6,101854-78-8,127531-11-7)

Guidance literature:

With hydrogenchloride; at 70 ℃; for 5h;

DOI:10.1016/S0040-4039(01)93841-9

Reference yield:

(R)-2,4-Diamino-butyric acid ethyl ester; hydrochloride (103668-08-2) → (R)-2,4-diaminobutyric acid dihydrochloride (1482-98-0,1883-09-6,6970-28-1,19391-83-4,26889-08-7,40149-78-8,57538-26-8,65427-54-5,66837-03-4,89700-93-6,101854-78-8,127531-11-7)

Guidance literature:

With hydrogenchloride; at 70 ℃; for 5h;

DOI:10.1016/S0040-4039(01)93841-9

upstream raw materials:

(S)-3-Cyano-2-[(1R,2R,5R)-2-hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-propionic acid ethyl ester

N^α,N^γ-bis(t-butoxycarbonyl)-L-α,γ-butyric acid

(R)-2,4-Diamino-butyric acid ethyl ester; hydrochloride

Downstream raw materials:

N^α,N^γ-diBoc-L-2,4-diaminobutyric acid p-nitrobenzyl ester

(3S)-3-aminopyrrolidin-2-one

(R)-2,4-bis((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid

(S)-2,4-bis(((benzyloxy)carbonyl)amino)butanoic acid

Refernces

• 1、 Solladie-Cavallo, A.,Simon, M. C.. "ENANTIOSELECTIVE SYNTHESIS OF OPTICALLY PURE NATURAL S(+) OR UNNATURAL R(-) DABA". . p. 6011 - 6014. Retrieved 2007/10/02.