5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethylpentyl)-3-methylphenyl]-propyl}-2-methylphenoxy)-4(S)-hydroxypentanoic acid

Base Information

Chemical Name:5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethylpentyl)-3-methylphenyl]-propyl}-2-methylphenoxy)-4(S)-hydroxypentanoic acid
CAS No.:865236-49-3
Molecular Formula:C₃₁H₄₆O₅
Molecular Weight:498.703
Hs Code.:

Synonyms:5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethylpentyl)-3-methylphenyl]-propyl}-2-methylphenoxy)-4(S)-hydroxypentanoic acid

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Chemical Property of 5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethylpentyl)-3-methylphenyl]-propyl}-2-methylphenoxy)-4(S)-hydroxypentanoic acid

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Technology Process of 5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethylpentyl)-3-methylphenyl]-propyl}-2-methylphenoxy)-4(S)-hydroxypentanoic acid

There total 5 articles about 5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethylpentyl)-3-methylphenyl]-propyl}-2-methylphenoxy)-4(S)-hydroxypentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: (S)-5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethylpentyl)-3-methylphenyl]-propyl}-2-methylphenoxymethyl)-dihydrofuran-2-one

: 865236-49-3
5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethylpentyl)-3-methylphenyl]-propyl}-2-methylphenoxy)-4(S)-hydroxypentanoic acid

Guidance literature:: (S)-5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethylpentyl)-3-methylphenyl]-propyl}-2-methylphenoxymethyl)-dihydrofuran-2-one; With sodium hydroxide; In methanol; at 60 ℃; for 0.5h;

With hydrogenchloride; In methanol; water;
DOI:10.1016/j.bmc.2011.07.001

Reference yield:

: 850918-02-4
4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethylpent-1-ynyl)-3-methylphenyl]-propyl}-2-methylphenol

: 865236-49-3
5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethylpentyl)-3-methylphenyl]-propyl}-2-methylphenoxy)-4(S)-hydroxypentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 0.5 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 70 °C

3: sodium hydroxide / methanol / 0.5 h / 60 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; sodium hydroxide; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.07.001

Reference yield:

: 55041-27-5
3,3-bis[4-hydroxy-3-methylphenyl]pentane

: 865236-49-3
5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethylpentyl)-3-methylphenyl]-propyl}-2-methylphenoxy)-4(S)-hydroxypentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 1 h / 0 - 20 °C

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / acetonitrile / 3 h / 80 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 0.5 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 70 °C

5: sodium hydroxide / methanol / 0.5 h / 60 °C

With pyridine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; sodium hydroxide; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 2: Sonogashira coupling;
DOI:10.1016/j.bmc.2011.07.001