(S)-2-(((Benzyloxy)carbonyl)amino)-3-cyclohexylpropanoic acid

Base Information

Chemical Name:(S)-2-(((Benzyloxy)carbonyl)amino)-3-cyclohexylpropanoic acid
CAS No.:25341-42-8
Molecular Formula:C17H23 N O4
Molecular Weight:305.374
Hs Code.:2924299090
DSSTox Substance ID:DTXSID50556769
Nikkaji Number:J2.297.262F
Mol file:25341-42-8.mol

Synonyms:25341-42-8;Z-Cha-OH;(S)-2-(((Benzyloxy)carbonyl)amino)-3-cyclohexylpropanoic acid;Z-3-cyclohexyl-L-alanine;cbz-3-cyclohexyl-l-alanine;(2S)-3-cyclohexyl-2-(phenylmethoxycarbonylamino)propanoic acid;MFCD00191081;(2S)-2-{[(BENZYLOXY)CARBONYL]AMINO}-3-CYCLOHEXYLPROPANOIC ACID;Z-L-Cha-OH;Z-beta-cyclohexyl-L-alanine;N-Benzyloxycarbonyl-L-3-cyclohexylalanine;Z-Cha-OH DHCA salt;Z-L-Cha-OH DHCA salt;SCHEMBL4622697;DTXSID50556769;MNABZONTQXNLDT-HNNXBMFYSA-N;CBZ-L-3-CYCLOHEXYL ALANINE;Z-Cha-OH dicyclohexylammonium salt;Z-3-cyclohexyl-L-alanine DHCA salt;AKOS015911046;N-Benzyloxycarbonyl-3-cyclohexylalanine;Z-beta-cyclohexyl-L-alanine DHCA salt;Z-Cha-OH, >=95.0% (HPLC);DS-18391;CS-0103659;F14549;EN300-1670923;N-[(Benzyloxy)carbonyl]-3-cyclohexyl-L-alanine;A851230;J-300443;2(S)-benzyloxycarbonylamino-3-cyclohexylpropionic acid;(S)-2-Benzyloxycarbonylamino-3-cyclohexyl-propionic acid;(S)-2-benzyloxycarbonylaMino-3-cyclohexylpropanoic acid;3-cyclohexyl-N-{[(phenylmethyl)oxy]carbonyl}-L-alanine;(S)-2-(benzyloxycarbonylamino)-3-cyclohexylpropanoic acid;N-(Benzyloxycarbonyl)-2(S)-amino-3-cyclohexylpropionic acid;N-alpha-BenZyloxycarbonyl-L-cyclohexylalanine (CbZ-L-Cha-OH)

Suppliers and Price of (S)-2-(((Benzyloxy)carbonyl)amino)-3-cyclohexylpropanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-2-(((Benzyloxy)carbonyl)amino)-3-cyclohexylpropanoicAcid
250mg
$ 55.00

Chem-Impex
Z-β-cyclohexyl-L-alanine ≥ 98% (HPLC)
25G
$ 110.00

Chem-Impex
Z-β-cyclohexyl-L-alanine,98%(HPLC) 98%(HPLC)
1G
$ 14.00

Chem-Impex
Z-β-cyclohexyl-L-alanine ≥ 98% (HPLC)
5G
$ 30.00

Chem-Impex
Z-β-cyclohexyl-L-alanine ≥ 98% (HPLC)
100G
$ 430.00

Chemenu
Z-Cha-OH 95%
25g
$ 128.00

Chemenu
Z-Cha-OH 95%
100g
$ 355.00

Biosynth Carbosynth
Z-beta-cyclohexyl-L-alanine
25 g
$ 300.00

Biosynth Carbosynth
Z-beta-cyclohexyl-L-alanine
5 g
$ 140.00

Biosynth Carbosynth
Z-beta-cyclohexyl-L-alanine
10 g
$ 200.00

Total 49 raw suppliers

Chemical Property of (S)-2-(((Benzyloxy)carbonyl)amino)-3-cyclohexylpropanoic acid

Chemical Property:

Boiling Point:501.4±43.0 °C(Predicted)
PKA:4.00±0.10(Predicted)
PSA：75.63000
Density:1.167
LogP:3.72730
Storage Temp.:2-8°C
XLogP3:4.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:305.16270821
Heavy Atom Count:22
Complexity:360

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-(((Benzyloxy)carbonyl)amino)-3-cyclohexylpropanoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(CC1)CC(C(=O)O)NC(=O)OCC2=CC=CC=C2
Isomeric SMILES:C1CCC(CC1)C[C@@H](C(=O)O)NC(=O)OCC2=CC=CC=C2

Technology Process of (S)-2-(((Benzyloxy)carbonyl)amino)-3-cyclohexylpropanoic acid

There total 10 articles about (S)-2-(((Benzyloxy)carbonyl)amino)-3-cyclohexylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 27527-05-5
L-cyclohexylalanine

: 501-53-1,94274-21-2
benzyl chloroformate

: 25341-42-8
(S)-2-benzyloxycarbonylamino-3-cyclohexylpropionic acid

Guidance literature:: With potassium carbonate; In tetrahydrofuran; water; at 0 - 20 ℃;

Reference yield:

: 4441-50-3,27527-05-5,55658-63-4,58717-02-5
β-cyclohexylalanine

: 501-53-1,94274-21-2
benzyl chloroformate

: 25341-42-8
(S)-2-benzyloxycarbonylamino-3-cyclohexylpropionic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; sodium hydroxide; diethyl ether; water; ethyl acetate;

Reference yield:

: 17193-39-4,144644-00-8
methyl 3-cyclohexyl-L-alaninate hydrochloride

: 25341-42-8
(S)-2-benzyloxycarbonylamino-3-cyclohexylpropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-dioxane

2: triethylamine

3: lithium hydroxide; water / tetrahydrofuran

With water; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.bmcl.2012.11.026