(E)-ethyl 3-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(trans-4-hydroxycyclohexylamino)-2-methylpyridin-3-yl)acrylate

Base Information

Chemical Name:(E)-ethyl 3-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(trans-4-hydroxycyclohexylamino)-2-methylpyridin-3-yl)acrylate
CAS No.:1552300-24-9
Molecular Formula:C₂₃H₃₁N₃O₃
Molecular Weight:397.517
Hs Code.:

Synonyms:(E)-ethyl 3-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(trans-4-hydroxycyclohexylamino)-2-methylpyridin-3-yl)acrylate

Suppliers and Price of (E)-ethyl 3-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(trans-4-hydroxycyclohexylamino)-2-methylpyridin-3-yl)acrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-ethyl 3-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(trans-4-hydroxycyclohexylamino)-2-methylpyridin-3-yl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-ethyl 3-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(trans-4-hydroxycyclohexylamino)-2-methylpyridin-3-yl)acrylate

There total 4 articles about (E)-ethyl 3-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(trans-4-hydroxycyclohexylamino)-2-methylpyridin-3-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1552300-16-9
trans-4-(3-bromo-6-(2,5-dimethyl-1H-pyrrol-1-yl)-2-methylpyridin-4-ylamino)cyclohexanol

: 140-88-5,9003-32-1
ethyl acrylate

: 1552300-24-9
(E)-ethyl 3-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(trans-4-hydroxycyclohexylamino)-2-methylpyridin-3-yl)acrylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; at 130 ℃; Sealed tube; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.12.112

Reference yield:

: 1541125-83-0
3-bromo-6-(2,5-dimethyl-1H-pyrrol-1-yl)-2-methylpyridine

: 1552300-24-9
(E)-ethyl 3-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(trans-4-hydroxycyclohexylamino)-2-methylpyridin-3-yl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - -30 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; 1-methyl-pyrrolidin-2-one / 24 h / 160 °C / Sealed tube

3.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 130 °C / Sealed tube; Inert atmosphere

With 1-methyl-pyrrolidin-2-one; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; triethylamine; diisopropylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane;
DOI:10.1016/j.bmcl.2013.12.112

Reference yield:

: 110-13-4
2,5-hexanedione

: 1552300-24-9
(E)-ethyl 3-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(trans-4-hydroxycyclohexylamino)-2-methylpyridin-3-yl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 6 h / Dean-Stark; Reflux

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - -30 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; 1-methyl-pyrrolidin-2-one / 24 h / 160 °C / Sealed tube

4.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 130 °C / Sealed tube; Inert atmosphere

With 1-methyl-pyrrolidin-2-one; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; toluene-4-sulfonic acid; triethylamine; diisopropylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; toluene;
DOI:10.1016/j.bmcl.2013.12.112