N-[4-(2-amino-9H-purin-6-yloxymethyl)-benzyl]-3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide

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Chemical Name:N-[4-(2-amino-9H-purin-6-yloxymethyl)-benzyl]-3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide
CAS No.:1291090-26-0
Molecular Formula:C₄₅H₅₂N₈O₈
Molecular Weight:832.957
Hs Code.:

N-[4-(2-amino-9H-purin-6-yloxymethyl)-benzyl]-3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide

Synonyms:N-[4-(2-amino-9H-purin-6-yloxymethyl)-benzyl]-3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide

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Chemical Property of N-[4-(2-amino-9H-purin-6-yloxymethyl)-benzyl]-3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide

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Technology Process of N-[4-(2-amino-9H-purin-6-yloxymethyl)-benzyl]-3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide

There total 11 articles about N-[4-(2-amino-9H-purin-6-yloxymethyl)-benzyl]-3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1291090-39-5
1-(8-(4-(dimethylamino)phenyl)-1,2-dimethyl-7-oxopyrano[3,2-e]indol-3(7H)-yl)-3,6,9,12-tetraoxapentadecan-15-oic acid

: 6-(4-aminomethylbenzyloxy)-9H-purin-2-amine

: 1291090-26-0
N-[4-(2-amino-9H-purin-6-yloxymethyl)-benzyl]-3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.tet.2011.01.075

Reference yield:

: 39895-56-2
4-hydroxymethyl-benzylamine

: 1291090-26-0
N-[4-(2-amino-9H-purin-6-yloxymethyl)-benzyl]-3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane

2: potassium tert-butylate / dimethyl sulfoxide

3: potassium carbonate / methanol

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With pyridine; potassium tert-butylate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.01.075

Reference yield:

: 680622-70-2
N-[4-(2-amino-9H-purin-6-yloxymethyl)benzyl]-2,2,2-trifluoroacetamide

: 1291090-26-0
N-[4-(2-amino-9H-purin-6-yloxymethyl)-benzyl]-3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.01.075