ethyl (E)-5,5-bis(phenylsulfonyl)-8-methyl-9-trimethylsilyl-7-nonen-2-ynoate

Base Information

Chemical Name:ethyl (E)-5,5-bis(phenylsulfonyl)-8-methyl-9-trimethylsilyl-7-nonen-2-ynoate
CAS No.:259879-53-3
Molecular Formula:C₂₇H₃₄O₆S₂Si
Molecular Weight:546.781
Hs Code.:

Synonyms:ethyl (E)-5,5-bis(phenylsulfonyl)-8-methyl-9-trimethylsilyl-7-nonen-2-ynoate

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Chemical Property of ethyl (E)-5,5-bis(phenylsulfonyl)-8-methyl-9-trimethylsilyl-7-nonen-2-ynoate

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Technology Process of ethyl (E)-5,5-bis(phenylsulfonyl)-8-methyl-9-trimethylsilyl-7-nonen-2-ynoate

There total 5 articles about ethyl (E)-5,5-bis(phenylsulfonyl)-8-methyl-9-trimethylsilyl-7-nonen-2-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 259879-65-7
5,5-bis(phenylsulfonyl)-2-methyl-1-trifluoroacetyloxy-2-pentene

: 259879-53-3
ethyl (E)-5,5-bis(phenylsulfonyl)-8-methyl-9-trimethylsilyl-7-nonen-2-ynoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 76 percent / Pd₂(dba)3*dba / tetrahydrofuran / 12 h / 23 °C

2.1: NaH / dimethylformamide / 0.5 h / 23 °C

2.2: 77 mg / dimethylformamide / 17 h / 23 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 70 mg / tetrahydrofuran; hexane / 1 h / -78 °C

With n-butyllithium; Pd₂(dba)4; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jo025812n

Reference yield:

: 259879-66-8
(E)-5,5-bis(phenylsulfonyl)-2-methyl-1-trimethylsilyl-2-pentene

: 259879-53-3
ethyl (E)-5,5-bis(phenylsulfonyl)-8-methyl-9-trimethylsilyl-7-nonen-2-ynoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / 23 °C

1.2: 77 mg / dimethylformamide / 17 h / 23 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 70 mg / tetrahydrofuran; hexane / 1 h / -78 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jo025812n

Reference yield:

: 3406-02-8
bis(phenylsulfonyl)methane

: 259879-53-3
ethyl (E)-5,5-bis(phenylsulfonyl)-8-methyl-9-trimethylsilyl-7-nonen-2-ynoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 98 percent / Pd₂(dba)3*(dba); dppe / tetrahydrofuran / 17 h / 23 °C

2.1: 83 percent / DMAP; i-PrEt₂N / CH₂Cl₂ / 2.5 h / 23 °C

3.1: 76 percent / Pd₂(dba)3*dba / tetrahydrofuran / 12 h / 23 °C

4.1: NaH / dimethylformamide / 0.5 h / 23 °C

4.2: 77 mg / dimethylformamide / 17 h / 23 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

5.2: 70 mg / tetrahydrofuran; hexane / 1 h / -78 °C

With dmap; n-butyllithium; Pd₂(dba)4; N,N-diethyl-N-isopropylamine; sodium hydride; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo025812n