tert-butyl-4'-<(2-n-butyl-4-oxo-1,3-diazaspiro<4.4>nonan-3-yl)methyl>biphenyl-2-carboxylate

Base Information

Chemical Name:tert-butyl-4'-<(2-n-butyl-4-oxo-1,3-diazaspiro<4.4>nonan-3-yl)methyl>biphenyl-2-carboxylate
CAS No.:151257-08-8
Molecular Formula:C₂₉H₃₈N₂O₃
Molecular Weight:462.632
Hs Code.:

Synonyms:tert-butyl-4'-<(2-n-butyl-4-oxo-1,3-diazaspiro<4.4>nonan-3-yl)methyl>biphenyl-2-carboxylate

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Chemical Property of tert-butyl-4'-<(2-n-butyl-4-oxo-1,3-diazaspiro<4.4>nonan-3-yl)methyl>biphenyl-2-carboxylate

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Technology Process of tert-butyl-4'-<(2-n-butyl-4-oxo-1,3-diazaspiro<4.4>nonan-3-yl)methyl>biphenyl-2-carboxylate

There total 11 articles about tert-butyl-4'-<(2-n-butyl-4-oxo-1,3-diazaspiro<4.4>nonan-3-yl)methyl>biphenyl-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 138401-20-4
tert-butyl-4'-<(2-n-butyl-4-oxo-1,3-diazaspiro<4.4>non-1-en-3-yl)methyl>biphenyl-2-carboxylate

: 151257-08-8
tert-butyl-4'-<(2-n-butyl-4-oxo-1,3-diazaspiro<4.4>nonan-3-yl)methyl>biphenyl-2-carboxylate

Guidance literature:: With sodium tetrahydroborate; In methanol; for 24h; Ambient temperature;
DOI:10.1021/jm00074a018

Reference yield:

: 114772-40-6
4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester

: 151257-08-8
tert-butyl-4'-<(2-n-butyl-4-oxo-1,3-diazaspiro<4.4>nonan-3-yl)methyl>biphenyl-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) O₂, methylene blue, 2.) NaOMe / 1.) DMF, irrad., 2.) a.) DMF, 0.25 h, b.) DMF, 1 h

2: 99 percent / NaBH₄ / methanol / 24 h / Ambient temperature

With sodium tetrahydroborate; oxygen; sodium methylate; methylene blue; In methanol;
DOI:10.1021/jm00074a018

Reference yield:

: 13820-09-2
trimethyl orthovalerate

: 151257-08-8
tert-butyl-4'-<(2-n-butyl-4-oxo-1,3-diazaspiro<4.4>nonan-3-yl)methyl>biphenyl-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / AcOH / CH₂Cl₂ / 1.25 h / 90 °C

2: 99 percent / NaBH₄ / methanol / 24 h / Ambient temperature

With sodium tetrahydroborate; acetic acid; In methanol; dichloromethane;
DOI:10.1021/jm00074a018