N-(3-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl)-1-methylpiperidin-4-amine

Base Information

Chemical Name:N-(3-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl)-1-methylpiperidin-4-amine
CAS No.:1401732-46-4
Molecular Formula:C₂₇H₃₁N₅O
Molecular Weight:441.576
Hs Code.:

Synonyms:N-(3-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl)-1-methylpiperidin-4-amine

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Chemical Property of N-(3-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl)-1-methylpiperidin-4-amine

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Technology Process of N-(3-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl)-1-methylpiperidin-4-amine

There total 5 articles about N-(3-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl)-1-methylpiperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41838-46-4
4-Amino-1-methylpiperidine

: 1401732-45-3
5-(3-chlorophenyl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine

: 1401732-46-4
N-(3-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl)-1-methylpiperidin-4-amine

Guidance literature:: With potassium tert-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In tert-butyl alcohol; at 80 ℃; for 12h; Inert atmosphere;

Reference yield:

: 62908-83-2
3-methyl-5-nitropyrazolo<3,4-b>pyridine

: 1401732-46-4
N-(3-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl)-1-methylpiperidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium on activated charcoal / ethanol / 5 h / 20 °C

2.1: hydrogen bromide; sodium nitrite / copper(I) bromide / water / 4 h / -5 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / -5 - 20 °C

3.2: 0 - 20 °C / Reflux

4.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 100 °C / Inert atmosphere; Sealed tube

5.1: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / tert-butyl alcohol / 12 h / 80 °C / Inert atmosphere

With potassium tert-butylate; hydrogen bromide; sodium hydride; caesium carbonate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; copper(I) bromide; tert-butyl XPhos; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;

Reference yield:

: 1186608-73-0
3-methyl-1H-pyrazolo[3,4-b]pyridin-5-amine

: 1401732-46-4
N-(3-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl)-1-methylpiperidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen bromide; sodium nitrite / copper(I) bromide / water / 4 h / -5 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / -5 - 20 °C

2.2: 0 - 20 °C / Reflux

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 100 °C / Inert atmosphere; Sealed tube

4.1: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / tert-butyl alcohol / 12 h / 80 °C / Inert atmosphere

With potassium tert-butylate; hydrogen bromide; sodium hydride; caesium carbonate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) bromide; tert-butyl XPhos; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;