ethyl (2S,3R,4S)-4-(t-butyldiphenylsilyloxy)-2,3-isopropylidenedioxy-4-phenylbutanoate

Base Information

Chemical Name:ethyl (2S,3R,4S)-4-(t-butyldiphenylsilyloxy)-2,3-isopropylidenedioxy-4-phenylbutanoate
CAS No.:252273-57-7
Molecular Formula:C₃₁H₃₈O₅Si
Molecular Weight:518.725
Hs Code.:

Synonyms:ethyl (2S,3R,4S)-4-(t-butyldiphenylsilyloxy)-2,3-isopropylidenedioxy-4-phenylbutanoate

Suppliers and Price of ethyl (2S,3R,4S)-4-(t-butyldiphenylsilyloxy)-2,3-isopropylidenedioxy-4-phenylbutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of ethyl (2S,3R,4S)-4-(t-butyldiphenylsilyloxy)-2,3-isopropylidenedioxy-4-phenylbutanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl (2S,3R,4S)-4-(t-butyldiphenylsilyloxy)-2,3-isopropylidenedioxy-4-phenylbutanoate

There total 6 articles about ethyl (2S,3R,4S)-4-(t-butyldiphenylsilyloxy)-2,3-isopropylidenedioxy-4-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 252273-56-6
ethyl (2S,3R,4S)-4-hydroxy-2,3-isopropylidenedioxy-4-phenylbutanoate

: 252273-57-7
ethyl (2S,3R,4S)-4-(t-butyldiphenylsilyloxy)-2,3-isopropylidenedioxy-4-phenylbutanoate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 96h;
DOI:10.1016/S0040-4020(99)00794-2

Reference yield:

: 187931-99-3
ethyl (4S,5S)-5-[(R)-{[(tert-butyl)(dimethyl)silyl]oxy}(phenyl)methyl]-2,2-dimethyl-1,3-dioxolane-4-carboxylate

: 252273-57-7
ethyl (2S,3R,4S)-4-(t-butyldiphenylsilyloxy)-2,3-isopropylidenedioxy-4-phenylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Et₃N*3HF / acetonitrile / 168 h / 20 °C

2: 97 percent / Ph₃P; ethyl azodicarboxylate / tetrahydrofuran / 1.75 h / 0 - 20 °C

3: 87 percent / K₂CO₃ / CH₂Cl₂; ethanol / 1 h / 20 °C

4: 94 percent / imidazole / dimethylformamide / 96 h / 20 °C

With 1H-imidazole; ethyl azodicarboxylate; potassium carbonate; triethylamine tris(hydrogen fluoride); triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: desilylation / 2: Mitsunobu reaction / 3: saponification / 4: silylation;
DOI:10.1016/S0040-4020(99)00794-2

Reference yield:

: 252273-55-5
ethyl (2S,3R,4S)-2,3-isopropylidenedioxy-4-(4-nitrobenzyloxy)-4-phenylbutanoate

: 252273-57-7
ethyl (2S,3R,4S)-4-(t-butyldiphenylsilyloxy)-2,3-isopropylidenedioxy-4-phenylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / K₂CO₃ / CH₂Cl₂; ethanol / 1 h / 20 °C

2: 94 percent / imidazole / dimethylformamide / 96 h / 20 °C

With 1H-imidazole; potassium carbonate; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: saponification / 2: silylation;
DOI:10.1016/S0040-4020(99)00794-2