5',3'-bis-O-tert-butyldimethylsilyl-5-[2-(4-N,N-dimethylaminophenyl)ethynyl]-2'-deoxyuridine

Base Information

Chemical Name:5',3'-bis-O-tert-butyldimethylsilyl-5-[2-(4-N,N-dimethylaminophenyl)ethynyl]-2'-deoxyuridine
CAS No.:289481-37-4
Molecular Formula:C₃₁H₄₉N₃O₅Si₂
Molecular Weight:599.918
Hs Code.:

Synonyms:5',3'-bis-O-tert-butyldimethylsilyl-5-[2-(4-N,N-dimethylaminophenyl)ethynyl]-2'-deoxyuridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5',3'-bis-O-tert-butyldimethylsilyl-5-[2-(4-N,N-dimethylaminophenyl)ethynyl]-2'-deoxyuridine

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Technology Process of 5',3'-bis-O-tert-butyldimethylsilyl-5-[2-(4-N,N-dimethylaminophenyl)ethynyl]-2'-deoxyuridine

There total 1 articles about 5',3'-bis-O-tert-butyldimethylsilyl-5-[2-(4-N,N-dimethylaminophenyl)ethynyl]-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.2%

: 148134-86-5
2'-deoxy-3',5'-bis(O-tert-butyldimethylsilyl)-5-iodouridine

: 17573-94-3,752235-18-0
4-ethynyl-N,N-dimethylaniline

: 289481-37-4
5',3'-bis-O-tert-butyldimethylsilyl-5-[2-(4-N,N-dimethylaminophenyl)ethynyl]-2'-deoxyuridine

Guidance literature:: 2'-deoxy-3',5'-bis(O-tert-butyldimethylsilyl)-5-iodouridine; With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane; Heating;

4-ethynyl-N,N-dimethylaniline; With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; at 60 ℃; for 2h;
DOI:10.1080/15257770008033027

Reference yield: 80.2%

: 289481-37-4
5',3'-bis-O-tert-butyldimethylsilyl-5-[2-(4-N,N-dimethylaminophenyl)ethynyl]-2'-deoxyuridine

: 289481-38-5
5',3'-bis-O-tert-butyldimethylsilyl-5-[2-(4-N,N-dimethylaminophenyl)ethyl]-2'-deoxyuridine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 48h; under 2585.74 Torr;
DOI:10.1080/15257770008033027