3-[4-({(4-chlorophenyl)-[4-(4-trifluoromethoxyphenyl)thiazol-2-yl]amino}methyl)benzoylamino]propionic acid

Base Information

Chemical Name:3-[4-({(4-chlorophenyl)-[4-(4-trifluoromethoxyphenyl)thiazol-2-yl]amino}methyl)benzoylamino]propionic acid
CAS No.:643011-49-8
Molecular Formula:C₂₇H₂₁ClF₃N₃O₄S
Molecular Weight:575.996
Hs Code.:

Synonyms:3-[4-({(4-chlorophenyl)-[4-(4-trifluoromethoxyphenyl)thiazol-2-yl]amino}methyl)benzoylamino]propionic acid

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Chemical Property of 3-[4-({(4-chlorophenyl)-[4-(4-trifluoromethoxyphenyl)thiazol-2-yl]amino}methyl)benzoylamino]propionic acid

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Technology Process of 3-[4-({(4-chlorophenyl)-[4-(4-trifluoromethoxyphenyl)thiazol-2-yl]amino}methyl)benzoylamino]propionic acid

There total 2 articles about 3-[4-({(4-chlorophenyl)-[4-(4-trifluoromethoxyphenyl)thiazol-2-yl]amino}methyl)benzoylamino]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 643012-95-7
3-[4-({(4-chlorophenyl)-[4-(4-trifluoromethoxyphenyl)thiazol-2-yl]amino}methyl)benzoylamino]propionic acid sodium salt

: 643011-49-8
3-[4-({(4-chlorophenyl)-[4-(4-trifluoromethoxyphenyl)thiazol-2-yl]amino}methyl)benzoylamino]propionic acid

Guidance literature:: With hydrogenchloride; In water;

Reference yield:

: Fmoc-β-Ala-Wang resin

: 106-47-8
4-chloro-aniline

: 619-66-9
4-Carboxybenzaldehyde

: 103962-10-3
2-bromo-1-(4-(trifluoromethoxy)phenyl)ethanone

: 199915-38-3
9-fluorenylmethoxycarbonyl isothiocyanate

: 643011-49-8
3-[4-({(4-chlorophenyl)-[4-(4-trifluoromethoxyphenyl)thiazol-2-yl]amino}methyl)benzoylamino]propionic acid

Guidance literature:: Fmoc-β-Ala-Wang resin; With piperidine; In 1-methyl-pyrrolidin-2-one; for 0.666667h; solid phase reaction;

4-Carboxybenzaldehyde; With benzotriazol-1-ol; diisopropyl-carbodiimide; In 1-methyl-pyrrolidin-2-one; acetonitrile; at 20 ℃; for 16h; solid phase reaction;

4-chloro-aniline; 2-bromo-1-(4-(trifluoromethoxy)phenyl)ethanone; 9-fluorenylmethoxycarbonyl isothiocyanate; Further stages;
DOI:10.1021/jm8016249