L-<4'-13C>tyrosine benzyl ester p-toluenesulfonate

Base Information

• Chemical Name: L-<4'-13C>tyrosine benzyl ester p-toluenesulfonate
• CAS No.: 100790-35-0
• Molecular Formula: C₇H₈O₃S*C₁₆H₁₇NO₃
• Molecular Weight: 444.51
• Mol file: 100790-35-0.mol

Synonyms:L-<4'-13C>tyrosine benzyl ester p-toluenesulfonate

Chemical Property of L-<4'-13C>tyrosine benzyl ester p-toluenesulfonate

Chemical Property:

Purity/Quality:

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Technology Process of L-<4'-13C>tyrosine benzyl ester p-toluenesulfonate

There total 4 articles about L-<4'-13C>tyrosine benzyl ester p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.1%

toluene-4-sulfonic acid (104-15-4) + L-<4'-13C>tyrosine (81201-90-3) + benzyl alcohol (100-51-6,185532-71-2) → L-<4'-13C>tyrosine benzyl ester p-toluenesulfonate (100790-35-0)

Guidance literature:

In benzene; Heating;

DOI:10.1021/jo00358a004

Reference yield:

<1-13C>-p-nitro-phenol (3881-07-0) → L-<4'-13C>tyrosine benzyl ester p-toluenesulfonate (100790-35-0)

Guidance literature:

Multi-step reaction with 4 steps

1: NaBH₄, aq. NaOH / 10percent Pd/C / H₂O / 0.67 h

2: 1.) NaNO₂, 2.) aq. hypophosphorous acid / 1.) H₂O, RT, 1 h, 2.) RT, 5 d

3: ammonium acetate / H₂O / 24 h / 37 °C / bacterial cells Erwinia herbicola, pH 8.5

4: 97.1 percent / benzene / Heating

With ammonium acetate; sodium hydroxide; sodium tetrahydroborate; hypophosphorous acid; sodium nitrite; palladium on activated charcoal; In water; benzene;

DOI:10.1021/jo00358a004

Reference yield:

<1-13C>phenol (29809-11-8) → L-<4'-13C>tyrosine benzyl ester p-toluenesulfonate (100790-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate / H₂O / 24 h / 37 °C / bacterial cells Erwinia herbicola, pH 8.5

2: 97.1 percent / benzene / Heating

With ammonium acetate; In water; benzene;

DOI:10.1021/jo00358a004

upstream raw materials:

toluene-4-sulfonic acid

L-<4'-13C>tyrosine

benzyl alcohol

<1-13C>phenol

Downstream raw materials:

L-<4'-13C>tyrosine benzyl ester 1-phenyltetrazolyl ether