5-amino-N-[5-(6-aminooxepan-3-yl)-1-methyl-pyrazol-4-yl]-2-(2,6-difluorophenyl)thiazole-4-carboxamide

Base Information

Chemical Name:5-amino-N-[5-(6-aminooxepan-3-yl)-1-methyl-pyrazol-4-yl]-2-(2,6-difluorophenyl)thiazole-4-carboxamide
CAS No.:1586039-83-9
Molecular Formula:C₂₀H₂₂F₂N₆O₂S
Molecular Weight:448.496
Hs Code.:

Synonyms:5-amino-N-[5-(6-aminooxepan-3-yl)-1-methyl-pyrazol-4-yl]-2-(2,6-difluorophenyl)thiazole-4-carboxamide

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Chemical Property of 5-amino-N-[5-(6-aminooxepan-3-yl)-1-methyl-pyrazol-4-yl]-2-(2,6-difluorophenyl)thiazole-4-carboxamide

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Technology Process of 5-amino-N-[5-(6-aminooxepan-3-yl)-1-methyl-pyrazol-4-yl]-2-(2,6-difluorophenyl)thiazole-4-carboxamide

There total 11 articles about 5-amino-N-[5-(6-aminooxepan-3-yl)-1-methyl-pyrazol-4-yl]-2-(2,6-difluorophenyl)thiazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1586043-89-1
tert-butyl N-[6-[4-[[5-(tert-butoxycarbonylamino)-2-(2,6-difluorophenyl)thiazole-4-carbonyl]amino]-2-methyl-pyrazol-3-yl]oxepan-3-yl]carbamate

: 3-(3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)tetrahydrofuran-3-ol

: 1586039-83-9
5-amino-N-[5-(6-aminooxepan-3-yl)-1-methyl-pyrazol-4-yl]-2-(2,6-difluorophenyl)thiazole-4-carboxamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol;

Reference yield:

: 1586043-78-8
5-[1-(allyloxymethyl)but-3-enyl]-1-methyl-4-nitro-pyrazole

: 1586039-83-9
5-amino-N-[5-(6-aminooxepan-3-yl)-1-methyl-pyrazol-4-yl]-2-(2,6-difluorophenyl)thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: toluene

2: dihydrogen peroxide / tetrahydrofuran; water

3: sodium hydrogencarbonate

4: acetic acid; ammonium acetate; sodium cyanoborohydride / methanol

5: methanol

6: hydrogenchloride / 1,4-dioxane; methanol

With ammonium acetate; hydrogenchloride; dihydrogen peroxide; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene;

Reference yield:

: 1586043-80-2
1-methyl-4-nitro-5-(2,3,4,5-tetrahydrooxepin-3-yl)pyrazole

: 1586039-83-9
5-amino-N-[5-(6-aminooxepan-3-yl)-1-methyl-pyrazol-4-yl]-2-(2,6-difluorophenyl)thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: dihydrogen peroxide / tetrahydrofuran; water

2: sodium hydrogencarbonate

3: acetic acid; ammonium acetate; sodium cyanoborohydride / methanol

4: methanol

5: hydrogenchloride / 1,4-dioxane; methanol

With ammonium acetate; hydrogenchloride; dihydrogen peroxide; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water;