5-bromo-1-(3-(tert-butyldimethylsilyloxy)-1-phenylpropyl)-3-nitro-1H-1,2,4-triazole

Base Information

Chemical Name:5-bromo-1-(3-(tert-butyldimethylsilyloxy)-1-phenylpropyl)-3-nitro-1H-1,2,4-triazole
CAS No.:1319068-62-6
Molecular Formula:C₁₇H₂₅BrN₄O₃Si
Molecular Weight:441.4
Hs Code.:

Synonyms:5-bromo-1-(3-(tert-butyldimethylsilyloxy)-1-phenylpropyl)-3-nitro-1H-1,2,4-triazole

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Chemical Property of 5-bromo-1-(3-(tert-butyldimethylsilyloxy)-1-phenylpropyl)-3-nitro-1H-1,2,4-triazole

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Technology Process of 5-bromo-1-(3-(tert-butyldimethylsilyloxy)-1-phenylpropyl)-3-nitro-1H-1,2,4-triazole

There total 2 articles about 5-bromo-1-(3-(tert-butyldimethylsilyloxy)-1-phenylpropyl)-3-nitro-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1319068-60-4
(3-bromo-3-phenylpropoxy)(tert-butyl)dimethylsilane

: 24807-56-5
5-bromo-3-nitro-1H-1,2,4-triazole

5-bromo-1-(3-(tert-butyldimethylsilyloxy)-1-phenylpropyl)-3-nitro-1H-1,2,4-triazole: 1319068-62-6
5-bromo-1-(3-(tert-butyldimethylsilyloxy)-1-phenylpropyl)-3-nitro-1H-1,2,4-triazole

Guidance literature:: With potassium carbonate; sodium iodide; In acetonitrile; at 60 - 85 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 69404-95-1
tert-butyldimethyl(3-phenylpropoxy)silane

5-bromo-1-(3-(tert-butyldimethylsilyloxy)-1-phenylpropyl)-3-nitro-1H-1,2,4-triazole: 1319068-62-6
5-bromo-1-(3-(tert-butyldimethylsilyloxy)-1-phenylpropyl)-3-nitro-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

2.1: sodium iodide / acetonitrile / 0.25 h / 20 °C / Inert atmosphere

2.2: 2.5 h / 60 - 85 °C

With N-Bromosuccinimide; sodium iodide; dibenzoyl peroxide; In tetrachloromethane; acetonitrile;

Reference yield: 61.0%

5-bromo-1-(3-(tert-butyldimethylsilyloxy)-1-phenylpropyl)-3-nitro-1H-1,2,4-triazole: 1319068-62-6
5-bromo-1-(3-(tert-butyldimethylsilyloxy)-1-phenylpropyl)-3-nitro-1H-1,2,4-triazole

: 1319068-64-8
2-nitro-7-phenyl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]oxazine

Guidance literature:: 5-bromo-1-(3-(tert-butyldimethylsilyloxy)-1-phenylpropyl)-3-nitro-1H-1,2,4-triazole; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

With water; In tetrahydrofuran; Inert atmosphere;