2-(2-(4-fluorophenyl)oxiran-2-yl)-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

Base Information

Chemical Name:2-(2-(4-fluorophenyl)oxiran-2-yl)-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine
CAS No.:1204246-95-6
Molecular Formula:C₁₈H₁₅FN₆O
Molecular Weight:350.355
Hs Code.:

Synonyms:2-(2-(4-fluorophenyl)oxiran-2-yl)-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

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Chemical Property of 2-(2-(4-fluorophenyl)oxiran-2-yl)-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

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Technology Process of 2-(2-(4-fluorophenyl)oxiran-2-yl)-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

There total 1 articles about 2-(2-(4-fluorophenyl)oxiran-2-yl)-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1204243-68-4
(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)methanone

: 5034-06-0
trimethyl sulfoxonium chloride

: 1204246-95-6
2-(2-(4-fluorophenyl)oxiran-2-yl)-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

Guidance literature:: trimethyl sulfoxonium chloride; With sodium hydride; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)methanone; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 3h;

Reference yield: 82.0%

: 1204246-95-6
2-(2-(4-fluorophenyl)oxiran-2-yl)-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

: 1-(4-fluorophenyl)-2-methoxy-1-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)ethanol

Guidance literature:: With sodium methylate; In methanol; at 60 ℃;

Reference yield: 35.0%

: 1204246-95-6
2-(2-(4-fluorophenyl)oxiran-2-yl)-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

: 530-62-1
1,1'-carbonyldiimidazole

: 1204245-00-0
5-(4-fluorophenyl)-5-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)oxazolidin-2-one

Guidance literature:: 2-(2-(4-fluorophenyl)oxiran-2-yl)-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine; With sodium azide; In N,N-dimethyl-formamide; at 85 ℃; for 3h;

With hydrogen; palladium 10% on activated carbon; In methanol; for 1h;

1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 - 65 ℃;