C₂₂H₂₂O₂

Base Information

• Chemical Name: C₂₂H₂₂O₂
• CAS No.: 1393376-12-9
• Molecular Formula: C₂₂H₂₂O₂
• Molecular Weight: 318.415
• Mol file: 1393376-12-9.mol

Synonyms:C₂₂H₂₂O₂

Chemical Property of C₂₂H₂₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₂O₂

There total 3 articles about C₂₂H₂₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

C18H18O3S (1393376-60-7) + 4-(4-methoxyphenyl)but-3-yn-2-ol (111887-18-4) → C22H22O2 (1393376-12-9)

Guidance literature:

4-(4-methoxyphenyl)but-3-yn-2-ol; With sodium hydride; In tetrahydrofuran; paraffin oil; at 0 ℃; for 0.333333h; Inert atmosphere;

C₁₈H₁₈O₃S; In tetrahydrofuran; paraffin oil; Inert atmosphere;

DOI:10.1002/anie.201202125

Reference yield:

C11H12O (1393376-59-4) → C22H22O2 (1393376-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; paraffin oil / 0.33 h / 0 °C / Inert atmosphere

2.2: Inert atmosphere

With sodium hydride; potassium hydroxide; In tetrahydrofuran; paraffin oil;

DOI:10.1002/anie.201202125

Reference yield:

2-bromostyrene (2039-88-5) → C22H22O2 (1393376-12-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: iodine; magnesium / tetrahydrofuran / Inert atmosphere

1.2: 20 - 60 °C / Inert atmosphere

2.1: potassium hydroxide / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; paraffin oil / 0.33 h / 0 °C / Inert atmosphere

3.2: Inert atmosphere

With iodine; sodium hydride; magnesium; potassium hydroxide; In tetrahydrofuran; paraffin oil; 1.2: Grignard reaction;

DOI:10.1002/anie.201202125

upstream raw materials:

C₁₁H₁₂O

C₁₈H₁₈O₃S

4-(4-methoxyphenyl)but-3-yn-2-ol

2-bromostyrene