benzyl (2S,3R)-3,4-epoxy-2-(3-methoxy-5-methylnaphthoyloxy)-3-methylbutanoate

Base Information

Chemical Name:benzyl (2S,3R)-3,4-epoxy-2-(3-methoxy-5-methylnaphthoyloxy)-3-methylbutanoate
CAS No.:937020-83-2
Molecular Formula:C₂₅H₂₄O₆
Molecular Weight:420.462
Hs Code.:

Synonyms:benzyl (2S,3R)-3,4-epoxy-2-(3-methoxy-5-methylnaphthoyloxy)-3-methylbutanoate

Suppliers and Price of benzyl (2S,3R)-3,4-epoxy-2-(3-methoxy-5-methylnaphthoyloxy)-3-methylbutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl (2S,3R)-3,4-epoxy-2-(3-methoxy-5-methylnaphthoyloxy)-3-methylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl (2S,3R)-3,4-epoxy-2-(3-methoxy-5-methylnaphthoyloxy)-3-methylbutanoate

There total 2 articles about benzyl (2S,3R)-3,4-epoxy-2-(3-methoxy-5-methylnaphthoyloxy)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 86535-59-3
5-Methyl-3-methoxy-1-naphthoyl chloride

: 184758-45-0
(S)-Hydroxy-((R)-2-methyl-oxiranyl)-acetic acid benzyl ester

: 937020-83-2
benzyl (2S,3R)-3,4-epoxy-2-(3-methoxy-5-methylnaphthoyloxy)-3-methylbutanoate

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 12h;
DOI:10.1021/jo7014888

Reference yield:

: 157087-28-0
(S)-benzyl 2-hydroxy-3-methylbut-3-enoate

: 937020-83-2
benzyl (2S,3R)-3,4-epoxy-2-(3-methoxy-5-methylnaphthoyloxy)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: Ti(i-PrO)4; D-(-)-diisopropyl tartrate; t-BuOOH

2: 75 percent / DMAP; (i-Pr)2NEt / CH₂Cl₂ / 12 h / 25 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; D-(-)-diisopropyl tartrate; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1: Sharpless asymmetric epoxidation;
DOI:10.1021/jo7014888

Reference yield:

: 937020-83-2
benzyl (2S,3R)-3,4-epoxy-2-(3-methoxy-5-methylnaphthoyloxy)-3-methylbutanoate

: 3-methoxy-5-methylnaphthalene-1-carboxylic acid {1-[1-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethoxypropylcarbamoyl]-2-hydroxyethylcarbamoyl}(2-methyloxiranyl)methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / tetrahydrofuran / 3 h / 25 °C / 760.05 Torr

2: 49 mg / EDCI; HOBt / CH₂Cl₂ / 12 h / 25 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo7014888