dimethyl (3R,4S)-(2-oxo-3,4-diphenyl-3,4-dihydro-2H-pyran-6-yl)phosphonate

Base Information

Chemical Name:dimethyl (3R,4S)-(2-oxo-3,4-diphenyl-3,4-dihydro-2H-pyran-6-yl)phosphonate
CAS No.:1598391-76-4
Molecular Formula:C₁₉H₁₉O₅P
Molecular Weight:358.331
Hs Code.:

Synonyms:dimethyl (3R,4S)-(2-oxo-3,4-diphenyl-3,4-dihydro-2H-pyran-6-yl)phosphonate

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Chemical Property of dimethyl (3R,4S)-(2-oxo-3,4-diphenyl-3,4-dihydro-2H-pyran-6-yl)phosphonate

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Technology Process of dimethyl (3R,4S)-(2-oxo-3,4-diphenyl-3,4-dihydro-2H-pyran-6-yl)phosphonate

There total 9 articles about dimethyl (3R,4S)-(2-oxo-3,4-diphenyl-3,4-dihydro-2H-pyran-6-yl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103-82-2
phenylacetic acid

: 149794-30-9
(2E-3-phenyl-prop-2-enonyl)-phosphonic acid dimethyl ester

: 1598391-76-4
dimethyl (3R,4S)-(2-oxo-3,4-diphenyl-3,4-dihydro-2H-pyran-6-yl)phosphonate

Guidance literature:: phenylacetic acid; With pivaloyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.333333h;

(2E-3-phenyl-prop-2-enonyl)-phosphonic acid dimethyl ester; With (2S,3R)-3-isopropyl-2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃; for 24h; stereoselective reaction;
DOI:10.1021/ol500873s

Reference yield:

: 103-82-2
phenylacetic acid

: 149794-30-9
(2E-3-phenyl-prop-2-enonyl)-phosphonic acid dimethyl ester

: 1598391-76-4
dimethyl (3R,4S)-(2-oxo-3,4-diphenyl-3,4-dihydro-2H-pyran-6-yl)phosphonate

: dimethyl (2-oxo-3,4-diphenyl-3,4-dihydro-2H-pyran-6-yl)phosphonate

Guidance literature:: phenylacetic acid; With pivaloyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.333333h;

(2E-3-phenyl-prop-2-enonyl)-phosphonic acid dimethyl ester; With (2S,3R)-3-isopropyl-2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃; for 24h; Temperature; Solvent;
DOI:10.1021/ol500873s

Reference yield:

: 103-82-2
phenylacetic acid

: 149794-30-9
(2E-3-phenyl-prop-2-enonyl)-phosphonic acid dimethyl ester

: 1598391-76-4
dimethyl (3R,4S)-(2-oxo-3,4-diphenyl-3,4-dihydro-2H-pyran-6-yl)phosphonate

: dimethyl (2-oxo-3,4-diphenyl-3,4-dihydro-2H-pyran-6-yl)phosphonate

: dimethyl (3S,4R)-(2-oxo-3,4-diphenyl-3,4-dihydro-2H-pyran-6-yl)phosphonate

Guidance literature:: phenylacetic acid; With pivaloyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.333333h;

(2E-3-phenyl-prop-2-enonyl)-phosphonic acid dimethyl ester; With (2S,3R)-3-isopropyl-2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 - 25 ℃; for 1h; Reagent/catalyst; Solvent;
DOI:10.1021/ol500873s