(R)-(-)-2-Methylglutaric Acid

Base Information

• Chemical Name: (R)-(-)-2-Methylglutaric Acid
• CAS No.: 1115-81-7
• Molecular Formula: C6H10O4
• Molecular Weight: 146.143
• Hs Code.: 2917190090
• European Community (EC) Number: 672-701-5
• UNII: 09DCX3K77W
• Nikkaji Number: J72.006B
• Wikidata: Q27236479
• Mol file: 1115-81-7.mol

Synonyms:1115-81-7;(R)-(-)-2-Methylglutaric Acid;(R)-2-Methylpentanedioic acid;(2R)-2-methylpentanedioic acid;(R)-(+)-2-Methylglutaric acid;(2R)-2-Methylglutaric acid;2-Methylglutaric acid, (-)-;Pentanedioic acid, 2-methyl-, (R)-;09DCX3K77W;2-Methylglutaric acid, (2R)-;2-Methylpentanedioic acid, (2R)-;(2~{R})-2-methylpentanedioic acid;Pentanedioic acid, 2-methyl-, (2R)-;(R)-(-)-2-Methylpentanedioic Acid;(-)-2-methylglutaric acid;UNII-09DCX3K77W;(R)-2-methyl glutaric acid;(R)-2-Methylpentanedioicacid;(-)-alpha-Methylglutaric acid;SCHEMBL7321898;Pentanedioicacid,2-methyl-,(2R)-;MFCD00671562;AKOS006378956;AKOS015840300;(-)-.ALPHA.-METHYLGLUTARIC ACID;AS-59833;CS-0063209;M1228;T71598;J-002601;Q27236479;E5N

Chemical Property of (R)-(-)-2-Methylglutaric Acid

Chemical Property:

• Vapor Pressure: 2.76E-05mmHg at 25°C
• Melting Point: 83 °C
• Refractive Index: -21 ° (C=5, H2O)
• Boiling Point: 332.7 °C at 760 mmHg
• PKA: 4.57±0.10(Predicted)
• Flash Point: 148.8 °C
• PSA: 74.60000
• Density: 1.246 g/cm³
• LogP: 0.57190
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly, Sonicated), DMSO (Slightly)
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 146.05790880
• Heavy Atom Count: 10
• Complexity: 141

Purity/Quality:

97% ^*data from raw suppliers

(R)-(-)-2-Methylglutaric Acid ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CCC(=O)O)C(=O)O
• Isomeric SMILES: C[C@H](CCC(=O)O)C(=O)O

Technology Process of (R)-(-)-2-Methylglutaric Acid

There total 29 articles about (R)-(-)-2-Methylglutaric Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C10H13NO7 → (R)-2-methylglutaric acid (1115-81-7)

Guidance literature:

With hydrogenchloride; water; at 110 ℃; for 5h; Inert atmosphere;

DOI:10.1021/ja102555a

Reference yield:

(-)-2-Methyl-glutarsaeure-1-methylester-5-<4-methoxycarbonyl-1,5-dimethylhexylester> (109943-05-7) → (+)-2-Methyl-glutarsaeure (617-62-9,1115-81-7,1115-82-8,18069-17-5)

Guidance literature:

Multistep reaction; (i) aq. K₂CO₃, (ii) MeI, (iii) K₂CO₃;

DOI:10.1016/S0040-4020(01)93252-1

Reference yield:

palmyrolide A → (R)-2-methylglutaric acid (1115-81-7)

Guidance literature:

palmyrolide A; With ozone; In dichloromethane; at 25 ℃; for 0.25h;

With formic acid; dihydrogen peroxide; at 70 ℃; for 0.333333h;

With hydrogenchloride; water; at 110 ℃; for 5h;

DOI:10.1021/ol101752n

upstream raw materials:

2-methylglutaric acid

strychnidin-10-one

ethyl 4-cyanopentanoate

1L-(1,2,4/3)-1-Methyl-2,3,4-cyclohexantriol

Downstream raw materials:

dimethyl (R)-(-)-2-methylglutarate