Technology Process of N-[(3,5-difluorophenyl)methyl]-5,8-dihydroxytetralin-2-carboxamide
There total 4 articles about N-[(3,5-difluorophenyl)methyl]-5,8-dihydroxytetralin-2-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-[(3,5-difluorophenyl)methyl]-5,8-dimethoxytetralin-2-carboxamide;
With
boron tribromide;
In
dichloromethane;
at -10 - 20 ℃;
for 17h;
With
methanol;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: chromium dichloride / tetrahydrofuran / 15.5 h / 0 - 20 °C
2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 19 h / 20 °C / Inert atmosphere
3: boron tribromide / dichloromethane / 17 h / -10 - 20 °C
With
chromium dichloride; boron tribromide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 19 h / 20 °C / Inert atmosphere
2: boron tribromide / dichloromethane / 17 h / -10 - 20 °C
With
boron tribromide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine;
In
dichloromethane;