ethyl 2-(3-bromobenzyl)-6-tert-butyldimethylsilyloxy-2-methylhexanoate

Base Information

Chemical Name:ethyl 2-(3-bromobenzyl)-6-tert-butyldimethylsilyloxy-2-methylhexanoate
CAS No.:273201-71-1
Molecular Formula:C₂₂H₃₇BrO₃Si
Molecular Weight:457.523
Hs Code.:

Synonyms:ethyl 2-(3-bromobenzyl)-6-tert-butyldimethylsilyloxy-2-methylhexanoate

Suppliers and Price of ethyl 2-(3-bromobenzyl)-6-tert-butyldimethylsilyloxy-2-methylhexanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 2-(3-bromobenzyl)-6-tert-butyldimethylsilyloxy-2-methylhexanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 2-(3-bromobenzyl)-6-tert-butyldimethylsilyloxy-2-methylhexanoate

There total 5 articles about ethyl 2-(3-bromobenzyl)-6-tert-butyldimethylsilyloxy-2-methylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 823-78-9
meta-bromobenzyl bromide

: 273201-70-0
ethyl 6-tert-butyldimethylsilyloxy-2-methylhexanoate

: 273201-71-1
ethyl 2-(3-bromobenzyl)-6-tert-butyldimethylsilyloxy-2-methylhexanoate

Guidance literature:: ethyl 6-tert-butyldimethylsilyloxy-2-methylhexanoate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h;

meta-bromobenzyl bromide; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; hexane; at -15 ℃; for 1h;
DOI:10.1021/jm990447m

Reference yield:

: 1191-25-9
6-Hydroxyhexanoic acid

: 273201-71-1
ethyl 2-(3-bromobenzyl)-6-tert-butyldimethylsilyloxy-2-methylhexanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: K₂CO₃ / dimethylformamide / 4 h / 80 °C

2.1: imidazole / dimethylformamide / 16 h / 23 °C

3.1: lithium diisopropylamide / hexane; tetrahydrofuran / 0.75 h / -78 °C

3.2: 96 percent / DMPU / hexane; tetrahydrofuran / 1 h / -15 °C

4.1: lithium diisopropylamide / hexane; tetrahydrofuran / 0.75 h / -78 °C

4.2: DMPU / hexane; tetrahydrofuran / 1 h / -15 °C

With 1H-imidazole; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 1.1: Esterification / 2.1: silylation / 3.1: Metallation / 3.2: Methylation / 4.1: Metallation / 4.2: Alkylation;
DOI:10.1021/jm990447m

Reference yield:

: 5299-60-5
6-hydroxy-hexanoic acid ethyl ester

: 273201-71-1
ethyl 2-(3-bromobenzyl)-6-tert-butyldimethylsilyloxy-2-methylhexanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: imidazole / dimethylformamide / 16 h / 23 °C

2.1: lithium diisopropylamide / hexane; tetrahydrofuran / 0.75 h / -78 °C

2.2: 96 percent / DMPU / hexane; tetrahydrofuran / 1 h / -15 °C

3.1: lithium diisopropylamide / hexane; tetrahydrofuran / 0.75 h / -78 °C

3.2: DMPU / hexane; tetrahydrofuran / 1 h / -15 °C

With 1H-imidazole; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 1.1: silylation / 2.1: Metallation / 2.2: Methylation / 3.1: Metallation / 3.2: Alkylation;
DOI:10.1021/jm990447m