Bicyclo[2.2.2]octane-1-carboxylic acid, 4-[4-Methyl-5-[2-(trifluoroMethyl)phenyl]-4H-1,2,4-triazol-3-yl]-

Base Information

Chemical Name:Bicyclo[2.2.2]octane-1-carboxylic acid, 4-[4-Methyl-5-[2-(trifluoroMethyl)phenyl]-4H-1,2,4-triazol-3-yl]-
CAS No.:935273-84-0
Molecular Formula:C₁₉H₂₀F₃N₃O₂
Molecular Weight:379.382
Hs Code.:
Mol file:935273-84-0.mol

Synonyms:4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]octane-1-carboxylic acid

Suppliers and Price of Bicyclo[2.2.2]octane-1-carboxylic acid, 4-[4-Methyl-5-[2-(trifluoroMethyl)phenyl]-4H-1,2,4-triazol-3-yl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4-(4-Methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octane-1-carboxylicacid 95+%
1g
$ 772.00

Chemenu
4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octane-1-carboxylicacid 95%
1g
$ 729.00

American Custom Chemicals Corporation
4-(4-METHYL-5-(2-(TRIFLUOROMETHYL)PHENYL)-4H-1,2,4-TRIAZOL-3-YL)BICYCLO[2.2.2]OCTANE-1-CARBOXYLIC ACID 95.00%
5MG
$ 497.98

Alichem
4-(4-Methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octane-1-carboxylicacid
1g
$ 621.72

Total 3 raw suppliers

Chemical Property of Bicyclo[2.2.2]octane-1-carboxylic acid, 4-[4-Methyl-5-[2-(trifluoroMethyl)phenyl]-4H-1,2,4-triazol-3-yl]-

Chemical Property:

Boiling Point:543.5±60.0 °C(Predicted)
PKA:4.77±0.10(Predicted)
Density:1.44±0.1 g/cm3(Predicted)
Storage Temp.:2-8°C

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

4-(4-Methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octane-1-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Bicyclo[2.2.2]octane-1-carboxylic acid, 4-[4-Methyl-5-[2-(trifluoroMethyl)phenyl]-4H-1,2,4-triazol-3-yl]-

There total 2 articles about Bicyclo[2.2.2]octane-1-carboxylic acid, 4-[4-Methyl-5-[2-(trifluoroMethyl)phenyl]-4H-1,2,4-triazol-3-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 719274-90-5
methyl 4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]octane-1-carboxylate

: 935273-84-0
4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]octane-1-carboxylic acid

Guidance literature:: methyl 4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]octane-1-carboxylate; With potassium hydroxide; water; In methanol; at 60 ℃; for 18h;

With hydrogenchloride; In water; pH=3;

Reference yield:

: C₂₀H₂₂F₃N₃O₂*ClH

: 935273-84-0
4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]octane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / dichloromethane; water

2.1: potassium hydroxide; water / methanol / 18 h / 60 °C

2.2: pH 3

With potassium hydroxide; water; sodium hydrogencarbonate; In methanol; dichloromethane; water;

Reference yield:

: 935273-84-0
4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]octane-1-carboxylic acid

: 719274-83-6
4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]octane-1-carboxamide

Guidance literature:: 4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]octane-1-carboxylic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 2h;

With ammonia; In dichloromethane; water; for 18h;