N-(tert-butoxycarbonyl)-(S)-(3,5-dichloro-4-methoxy)phenylglycine methyl ester

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-(S)-(3,5-dichloro-4-methoxy)phenylglycine methyl ester
CAS No.:193073-70-0
Molecular Formula:C₁₅H₁₉Cl₂NO₅
Molecular Weight:364.226
Hs Code.:

Synonyms:N-(tert-butoxycarbonyl)-(S)-(3,5-dichloro-4-methoxy)phenylglycine methyl ester

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Chemical Property of N-(tert-butoxycarbonyl)-(S)-(3,5-dichloro-4-methoxy)phenylglycine methyl ester

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Technology Process of N-(tert-butoxycarbonyl)-(S)-(3,5-dichloro-4-methoxy)phenylglycine methyl ester

There total 3 articles about N-(tert-butoxycarbonyl)-(S)-(3,5-dichloro-4-methoxy)phenylglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 193073-62-0
(S)-Amino-(3,5-dichloro-4-methoxy-phenyl)-acetic acid methyl ester

: 193073-70-0
N-(tert-butoxycarbonyl)-(S)-(3,5-dichloro-4-methoxy)phenylglycine methyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran;
DOI:10.1016/S0040-4039(97)00938-6

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: (S)-(3,5-dichloro-4-methoxy)phenylglycine methyl ester hydrochloride

: 193073-70-0
N-(tert-butoxycarbonyl)-(S)-(3,5-dichloro-4-methoxy)phenylglycine methyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.3987/COM-99-8514

Reference yield:

: 193073-55-1
[(S)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetic acid methyl ester

: 193073-70-0
N-(tert-butoxycarbonyl)-(S)-(3,5-dichloro-4-methoxy)phenylglycine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Pb(OAc)4; phosphate buffer / CH₂Cl₂; methanol / 0.5 h / 0 °C / pH 7

1.2: HCl / diethyl ether / 3 h / 20 °C

2.1: N(C₂H₅)3 / tetrahydrofuran / 5 h / 20 °C

With lead(IV) acetate; phosphate buffer; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 1.1: oxidative cleavage / 1.2: Hydrolysis / 2.1: Acylation;
DOI:10.3987/COM-99-8514