2-(Thiophen-2-yl)acetaldehyde

Base Information

• Chemical Name: 2-(Thiophen-2-yl)acetaldehyde
• CAS No.: 15022-15-8
• Molecular Formula: C6H6OS
• Molecular Weight: 126.179
• Hs Code.: 2934999090
• European Community (EC) Number: 870-775-5
• DSSTox Substance ID: DTXSID60424006
• Nikkaji Number: J675.703K
• Wikidata: Q82236405
• Mol file: 15022-15-8.mol

Synonyms:2-(thiophen-2-yl)acetaldehyde;15022-15-8;2-Thiopheneacetaldehyde;2-thiophen-2-ylacetaldehyde;thienylethanal;2-thienylacetaldehyde;thiophene-2-acetaldehyde;(2-Thienyl)acetaldehyde;SCHEMBL286875;DTXSID60424006;MFCD11592444;AKOS011897131;AS-50017;CS-0038150;FT-0712058;EN300-300723;O10539;Z993017816

Chemical Property of 2-(Thiophen-2-yl)acetaldehyde

Chemical Property:

• Boiling Point: 203.4 °C at 760 mmHg
• Flash Point: 76.8 °C
• PSA: 45.31000
• Density: 1.157 g/cm³
• LogP: 1.48950
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 126.01393598
• Heavy Atom Count: 8
• Complexity: 82.6

Purity/Quality:

99% ^*data from raw suppliers

2-(Thiophen-2-yl)acetaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1)CC=O

Technology Process of 2-(Thiophen-2-yl)acetaldehyde

There total 23 articles about 2-(Thiophen-2-yl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-thiophenethanol (5402-55-1) → 2-thienylacetaldehyde (15022-15-8)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In acetonitrile; at 80 ℃; for 2h;

DOI:10.1055/s-0030-1261032

Reference yield: 79.0%

methyl 2-thiopheneacetate (19432-68-9) → 2-thienylacetaldehyde (15022-15-8)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 0.5h;

DOI:10.1002/ejoc.201000434

Reference yield: 73.0%

2-thiophen-2-yl-oxirane (66256-03-9) → 2-thienylacetaldehyde (15022-15-8)

Guidance literature:

With silica gel; In ethyl acetate; Ambient temperature;

DOI:10.1080/00397919508011817

upstream raw materials:

N,N'-(2-[2]thienyl-ethylidene)-bis-carbamic acid diethyl ester

thiophene-2-carbaldehyde

2-thiophen-2-yl-oxirane

2-thiophenethanol

Downstream raw materials:

ethyl 3-benzyl-5-methyl-2-thiophen-2-ylmethyl-3H-imidazole-4-carboxylate

1-((2-thiophen-2-yl)ethylidene)-2-(2,4-dinitrophenyl)hydrazine

1-phenyl-4-(thiophene-2-yl)-1H-1,2,3-triazole

2-ethylthiophene

Refernces

• 1、 Dullaghan,Nord. "-". . p. 878,879, 880. Retrieved 1953.
• 2、 -. "NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF". Paragraph 00366. . Retrieved 2020/12/01.
• 3、 Li, Shenhuan,Li, Jie,Xia, Tianlai,Zhao, Wanxiang. "Stereoselective Synthesis of Vinylboronates by Rh-Catalyzed Borylation of Stereoisomeric Mixtures". supporting information. p. 462 - 468. Retrieved 2019/03/28.