[(S)-6-(4-Cyano-benzoylamino)-chroman-3-yl]-acetic acid ethyl ester

Base Information

• Chemical Name: [(S)-6-(4-Cyano-benzoylamino)-chroman-3-yl]-acetic acid ethyl ester
• CAS No.: 214401-71-5
• Molecular Formula: C₂₁H₂₀N₂O₄
• Molecular Weight: 364.401
• Mol file: 214401-71-5.mol

Synonyms:[(S)-6-(4-Cyano-benzoylamino)-chroman-3-yl]-acetic acid ethyl ester

Chemical Property of [(S)-6-(4-Cyano-benzoylamino)-chroman-3-yl]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of [(S)-6-(4-Cyano-benzoylamino)-chroman-3-yl]-acetic acid ethyl ester

There total 2 articles about [(S)-6-(4-Cyano-benzoylamino)-chroman-3-yl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-cyanobenzoyl chlorIde (6068-72-0) + ethyl (S)-(6-amino-3,4-dihydro-2H-1-benzopyran-3-yl)acetate (214401-69-1) → [(S)-6-(4-Cyano-benzoylamino)-chroman-3-yl]-acetic acid ethyl ester (214401-71-5)

Guidance literature:

With triethylamine; In chloroform; at 0 ℃; for 2h;

DOI:10.1021/jm9801859

Reference yield:

((S)-6-tert-Butoxycarbonylamino-chroman-3-yl)-acetic acid methyl ester → [(S)-6-(4-Cyano-benzoylamino)-chroman-3-yl]-acetic acid ethyl ester (214401-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) HCl(gas), 2.) H₂SO₄ / 1.) 60 deg C, 4 h, 2.) reflux, 4 h

2: 93 percent / Et₃N / CHCl₃ / 2 h / 0 °C

With hydrogenchloride; sulfuric acid; triethylamine; In chloroform;

DOI:10.1021/jm9801859

Reference yield:

[(S)-6-(4-Cyano-benzoylamino)-chroman-3-yl]-acetic acid ethyl ester (214401-71-5) → [(S)-6-(4-Carbamoyl-benzoylamino)-chroman-3-yl]-acetic acid ethyl ester

Guidance literature:

With hydrogenchloride; In ethanol; for 4h; Ambient temperature;

DOI:10.1021/jm9801859

upstream raw materials:

4-cyanobenzoyl chlorIde

ethyl (S)-(6-amino-3,4-dihydro-2H-1-benzopyran-3-yl)acetate