2-[2-(dimethyl(phenyl)silyl)-1H-indol-3-yl]acetic acid methyl ester

Base Information

• Chemical Name: 2-[2-(dimethyl(phenyl)silyl)-1H-indol-3-yl]acetic acid methyl ester
• CAS No.: 1234713-44-0
• Molecular Formula: C₁₉H₂₁NO₂Si
• Molecular Weight: 323.467
• Mol file: 1234713-44-0.mol

Synonyms:2-[2-(dimethyl(phenyl)silyl)-1H-indol-3-yl]acetic acid methyl ester

Chemical Property of 2-[2-(dimethyl(phenyl)silyl)-1H-indol-3-yl]acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-[2-(dimethyl(phenyl)silyl)-1H-indol-3-yl]acetic acid methyl ester

There total 2 articles about 2-[2-(dimethyl(phenyl)silyl)-1H-indol-3-yl]acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

o-((methoxycarbonyl)etheneyl)phenyl isocyanide (415725-18-7) + dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane (185990-03-8) → 2-[2-(dimethyl(phenyl)silyl)-1H-indol-3-yl]acetic acid methyl ester (1234713-44-0)

Guidance literature:

With methanol; copper (I) acetate; triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jo101024f

Reference yield: 38.0%

Indole-3-acetic acid methyl ester (1912-33-0) + Dimethylphenylsilane (766-77-8) → 2-[2-(dimethyl(phenyl)silyl)-1H-indol-3-yl]acetic acid methyl ester (1234713-44-0) + methyl 2-(1-(dimethyl(phenyl)silyl)-1H-indol-3-yl)acetate

Guidance literature:

With norborn-2-ene; carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); In toluene; at 135 ℃; for 20h; Inert atmosphere;

DOI:10.1039/c6cc00803h

upstream raw materials:

o-((methoxycarbonyl)etheneyl)phenyl isocyanide

dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane

Indole-3-acetic acid methyl ester

Dimethylphenylsilane