(S)-methyl 10,10-dibromo-6-ethyl-4-oxo-3-((phenylsulfonyl)oxy)-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepine-2-carboxylate

Base Information

Chemical Name:(S)-methyl 10,10-dibromo-6-ethyl-4-oxo-3-((phenylsulfonyl)oxy)-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepine-2-carboxylate
CAS No.:1220511-65-8
Molecular Formula:C₁₈H₁₈Br₂N₂O₇S
Molecular Weight:566.224
Hs Code.:

Synonyms:(S)-methyl 10,10-dibromo-6-ethyl-4-oxo-3-((phenylsulfonyl)oxy)-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepine-2-carboxylate

Suppliers and Price of (S)-methyl 10,10-dibromo-6-ethyl-4-oxo-3-((phenylsulfonyl)oxy)-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-methyl 10,10-dibromo-6-ethyl-4-oxo-3-((phenylsulfonyl)oxy)-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-methyl 10,10-dibromo-6-ethyl-4-oxo-3-((phenylsulfonyl)oxy)-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepine-2-carboxylate

There total 9 articles about (S)-methyl 10,10-dibromo-6-ethyl-4-oxo-3-((phenylsulfonyl)oxy)-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-methyl 6-ethyl-4-oxo-3-((phenylsulfonyl)oxy)-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepine-2-carboxylate

: (6S,10S)-methyl 10-bromo-6-ethyl-4-oxo-3-((phenylsulfonyl)oxy)-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepine-2-carboxylate

: 1220511-65-8
(S)-methyl 10,10-dibromo-6-ethyl-4-oxo-3-((phenylsulfonyl)oxy)-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepine-2-carboxylate

Guidance literature:: (S)-methyl 6-ethyl-4-oxo-3-((phenylsulfonyl)oxy)-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepine-2-carboxylate; With N-Bromosuccinimide; nitric acid; acetic acid; at 72 - 80 ℃; for 3.5h; Industry scale;

With KH₂PO₄; In dichloromethane; water; Industry scale;

Reference yield:

: (E)-3-(((Z)-4-((tert-butyldimethylsilyl)oxy)but-2-en-1-yl)oxy)-N'-hydroxypropanimidamide

: (6S,10S)-methyl 10-bromo-6-ethyl-4-oxo-3-((phenylsulfonyl)oxy)-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepine-2-carboxylate

: 1220511-65-8
(S)-methyl 10,10-dibromo-6-ethyl-4-oxo-3-((phenylsulfonyl)oxy)-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepine-2-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: methanol / 0.75 h / -20 - 5 °C / Inert atmosphere; Large scale

2: o-xylene / 5 h / 143 - 145 °C / Inert atmosphere; Large scale

3: pyridine / 2.5 h / 25 - 30 °C / Inert atmosphere; Large scale

4: hydrogenchloride / water; acetonitrile / 1 h / 15 - 18 °C / Inert atmosphere; Large scale

5: pyridine / isopropyl alcohol / 3 h / 75 °C / Inert atmosphere; Large scale

6: (1R,2R)-(+)-1,2-diaminocyclohexane-N,N’-bis(2-diphenylphosphino-1-naphthoyl); tetrabutylammomium bromide; tris-(dibenzylideneacetone)dipalladium(0) / dichloromethane / Inert atmosphere; Large scale

7: hydrogen / dichloromethane / 30 °C / 2327.23 Torr / Autoclave; Large scale

8: acetic acid; nitric acid; N-Bromosuccinimide / 4 h / 72 - 80 °C / Inert atmosphere

With pyridine; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; tetrabutylammomium bromide; hydrogen; nitric acid; acetic acid; (1R,2R)-(+)-1,2-diaminocyclohexane-N,N’-bis(2-diphenylphosphino-1-naphthoyl); In methanol; dichloromethane; o-xylene; water; isopropyl alcohol; acetonitrile;
DOI:10.1055/s-0040-1707994

Reference yield:

: dimethyl 2-(((E)-(1-amino-3-(((Z)-4-((tert-butyldimethylsilyl)oxy)but-2-en-1-yl)oxy)propylidene)amino)oxy)but-2-enedioate

: (6S,10S)-methyl 10-bromo-6-ethyl-4-oxo-3-((phenylsulfonyl)oxy)-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepine-2-carboxylate

: 1220511-65-8
(S)-methyl 10,10-dibromo-6-ethyl-4-oxo-3-((phenylsulfonyl)oxy)-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepine-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: o-xylene / 5 h / 143 - 145 °C / Inert atmosphere; Large scale

2: pyridine / 2.5 h / 25 - 30 °C / Inert atmosphere; Large scale

3: hydrogenchloride / water; acetonitrile / 1 h / 15 - 18 °C / Inert atmosphere; Large scale

4: pyridine / isopropyl alcohol / 3 h / 75 °C / Inert atmosphere; Large scale

5: (1R,2R)-(+)-1,2-diaminocyclohexane-N,N’-bis(2-diphenylphosphino-1-naphthoyl); tetrabutylammomium bromide; tris-(dibenzylideneacetone)dipalladium(0) / dichloromethane / Inert atmosphere; Large scale

6: hydrogen / dichloromethane / 30 °C / 2327.23 Torr / Autoclave; Large scale

7: acetic acid; nitric acid; N-Bromosuccinimide / 4 h / 72 - 80 °C / Inert atmosphere

With pyridine; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; tetrabutylammomium bromide; hydrogen; nitric acid; acetic acid; (1R,2R)-(+)-1,2-diaminocyclohexane-N,N’-bis(2-diphenylphosphino-1-naphthoyl); In dichloromethane; o-xylene; water; isopropyl alcohol; acetonitrile;
DOI:10.1055/s-0040-1707994