1-<3'-O-acetyl-2-deoxy-5-O-(4,4'-dimethoxytrityl)-α-D-pentofuranosyl>-5-methyl-4-(1,2,4-triazolyl)pyrimidine-2(1H)-one

Base Information

• Chemical Name: 1-<3'-O-acetyl-2-deoxy-5-O-(4,4'-dimethoxytrityl)-α-D-pentofuranosyl>-5-methyl-4-(1,2,4-triazolyl)pyrimidine-2(1H)-one
• CAS No.: 219706-26-0
• Molecular Formula: C₃₅H₃₅N₅O₇
• Molecular Weight: 637.692

Synonyms:1-<3'-O-acetyl-2-deoxy-5-O-(4,4'-dimethoxytrityl)-α-D-pentofuranosyl>-5-methyl-4-(1,2,4-triazolyl)pyrimidine-2(1H)-one

Chemical Property of 1-<3'-O-acetyl-2-deoxy-5-O-(4,4'-dimethoxytrityl)-α-D-pentofuranosyl>-5-methyl-4-(1,2,4-triazolyl)pyrimidine-2(1H)-one

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Technology Process of 1-<3'-O-acetyl-2-deoxy-5-O-(4,4'-dimethoxytrityl)-α-D-pentofuranosyl>-5-methyl-4-(1,2,4-triazolyl)pyrimidine-2(1H)-one

There total 2 articles about 1-<3'-O-acetyl-2-deoxy-5-O-(4,4'-dimethoxytrityl)-α-D-pentofuranosyl>-5-methyl-4-(1,2,4-triazolyl)pyrimidine-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1,2,4-Triazole (288-88-0) + 3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-α-thymidine (219706-25-9) → 1-<3'-O-acetyl-2-deoxy-5-O-(4,4'-dimethoxytrityl)-α-D-pentofuranosyl>-5-methyl-4-(1,2,4-triazolyl)pyrimidine-2(1H)-one (219706-26-0)

Guidance literature:

With triethylamine; trichlorophosphate; In acetonitrile; 0 deg C, 30 min, rt, 3 h;

DOI:10.1080/07328319808004323

Reference yield:

5'-O-(4,4'-dimethoxytrityl)-α-thymidine (104766-16-7) → 1-<3'-O-acetyl-2-deoxy-5-O-(4,4'-dimethoxytrityl)-α-D-pentofuranosyl>-5-methyl-4-(1,2,4-triazolyl)pyrimidine-2(1H)-one (219706-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / pyridine / 0 deg C, 1 h, rt, 8h

2: 85 percent / Et₃N, POCl₃ / acetonitrile / 0 deg C, 30 min, rt, 3 h

With triethylamine; trichlorophosphate; In pyridine; acetonitrile;

DOI:10.1080/07328319808004323

Reference yield: 92.0%

1-<3'-O-acetyl-2-deoxy-5-O-(4,4'-dimethoxytrityl)-α-D-pentofuranosyl>-5-methyl-4-(1,2,4-triazolyl)pyrimidine-2(1H)-one (219706-26-0) → 3'-O-acetyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-α-cytidine (219706-37-3)

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; for 2h; Ambient temperature;

DOI:10.1080/07328319808004323

upstream raw materials:

1,2,4-Triazole

3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-α-thymidine

5'-O-(4,4'-dimethoxytrityl)-α-thymidine

Downstream raw materials:

Acetic acid (2R,3S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{5-methyl-2-oxo-4-[(pyren-1-ylmethyl)-amino]-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester

3'-O-acetyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-α-cytidine

N⁴-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-α-cytidine

3'-O-acetyl-N⁴-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-α-cytidine

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