(1R,2R)-5-(tert-butyldiphenylsilyloxy)-1-methoxymethoxy-1-phenyl-pent-3-yn-2-ol

Base Information

• Chemical Name: (1R,2R)-5-(tert-butyldiphenylsilyloxy)-1-methoxymethoxy-1-phenyl-pent-3-yn-2-ol
• CAS No.: 211614-44-7
• Molecular Formula: C₂₉H₃₄O₄Si
• Molecular Weight: 474.672

Synonyms:(1R,2R)-5-(tert-butyldiphenylsilyloxy)-1-methoxymethoxy-1-phenyl-pent-3-yn-2-ol

Chemical Property of (1R,2R)-5-(tert-butyldiphenylsilyloxy)-1-methoxymethoxy-1-phenyl-pent-3-yn-2-ol

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Technology Process of (1R,2R)-5-(tert-butyldiphenylsilyloxy)-1-methoxymethoxy-1-phenyl-pent-3-yn-2-ol

There total 1 articles about (1R,2R)-5-(tert-butyldiphenylsilyloxy)-1-methoxymethoxy-1-phenyl-pent-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

C19H21BrMgOSi + methyl (R)-(methoxymethoxy)(phenyl)ethanoate (211614-43-6) → (1R,2R)-5-(tert-butyldiphenylsilyloxy)-1-methoxymethoxy-1-phenyl-pent-3-yn-2-ol (211614-44-7)

Guidance literature:

methyl (R)-(methoxymethoxy)(phenyl)ethanoate; With diisobutylaluminium hydride; In diethyl ether; pentane; at -78 ℃; for 1h;

C₁₉H₂₁BrMgOSi; In diethyl ether; pentane;

DOI:10.1016/S0040-4020(01)00689-5

Reference yield: 90.0%

(1R,2R)-5-(tert-butyldiphenylsilyloxy)-1-methoxymethoxy-1-phenyl-pent-3-yn-2-ol (211614-44-7) → (1R,2R)-5-(tert-Butyl-diphenyl-silanyloxy)-1-methoxymethoxy-1-phenyl-pentan-2-ol

Guidance literature:

With hydrogen; platinum(IV) oxide;

DOI:10.1016/S0040-4039(01)00984-4

Reference yield: 72.0%

(1R,2R)-5-(tert-butyldiphenylsilyloxy)-1-methoxymethoxy-1-phenyl-pent-3-yn-2-ol (211614-44-7) → (1R,2R,3E)-5-(tert-butyldiphenylsilyloxy)-1-methoxymethoxy-1-phenyl-pent-3-ene-2-ol (211614-45-8)

Guidance literature:

With bis-(2-methoxyethoxy)aluminium hydride; In diethyl ether; toluene; at -25 ℃; for 5h;

DOI:10.1021/jo980396l

upstream raw materials:

methyl (R)-(methoxymethoxy)(phenyl)ethanoate

Downstream raw materials:

(1R,2R,3E)-5-(tert-butyldiphenylsilyloxy)-1-methoxymethoxy-1-phenyl-pent-3-ene-2-ol

(1R,2R,3E)-1-phenyl-pent-3-en-1,2,5-triol

(E)-3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]prop-2-en-1-ol

(1R,2R,3S,4R)-1,2-di-O-isopropylidene-4,5-epoxy-3-methyl-1-phenyl-pentan-1,2-diol

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