2-Phenoxy-N-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-acetamide

Base Information

Chemical Name:2-Phenoxy-N-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-acetamide
CAS No.:166593-47-1
Molecular Formula:C₃₃H₅₁N₅O₇Si₂
Molecular Weight:685.968
Hs Code.:

2-Phenoxy-N-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-acetamide

Synonyms:2-Phenoxy-N-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-acetamide

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Chemical Property of 2-Phenoxy-N-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-acetamide

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Technology Process of 2-Phenoxy-N-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-acetamide

There total 5 articles about 2-Phenoxy-N-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 144782-24-1
N²-Phenoxyacetyl-2-aminopurine

: 166593-40-4
2,2,2-Trichloro-acetimidic acid (2S,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl ester

: 166593-47-1
2-Phenoxy-N-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-acetamide

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; Ambient temperature;
DOI:10.1016/S0040-4039(00)75987-9

Reference yield:

: 50-69-1
D-ribose

: 166593-47-1
2-Phenoxy-N-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / HCl / 20 °C

2: 90 percent / pyridine / Ambient temperature

3: 1.) DMAP; 2.) PPh₃, Pd(OAc)2 / 1.) acetonitrile, RT; 2.) toluene, reflux

4: 92 percent / H₂ / 10 percent Pd/C / ethyl acetate / Ambient temperature

5: 75 percent / DBU / 1,2-dichloro-ethane / Ambient temperature

6: 77 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / Ambient temperature

With pyridine; hydrogenchloride; dmap; palladium diacetate; trimethylsilyl trifluoromethanesulfonate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; palladium on activated charcoal; In ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(00)75987-9

Reference yield:

: 117363-13-0
benzyl 3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranoside

: 166593-47-1
2-Phenoxy-N-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) DMAP; 2.) PPh₃, Pd(OAc)2 / 1.) acetonitrile, RT; 2.) toluene, reflux

2: 92 percent / H₂ / 10 percent Pd/C / ethyl acetate / Ambient temperature

3: 75 percent / DBU / 1,2-dichloro-ethane / Ambient temperature

4: 77 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / Ambient temperature

With dmap; palladium diacetate; trimethylsilyl trifluoromethanesulfonate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; palladium on activated charcoal; In ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(00)75987-9