[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-yl]-(4-nitrophenyl)methanone

Base Information

Chemical Name:[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-yl]-(4-nitrophenyl)methanone
CAS No.:1310689-21-4
Molecular Formula:C₂₁H₂₂N₄O₄
Molecular Weight:394.43
Hs Code.:

Synonyms:[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-yl]-(4-nitrophenyl)methanone

Suppliers and Price of [1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-yl]-(4-nitrophenyl)methanone

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Chemical Property of [1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-yl]-(4-nitrophenyl)methanone

Chemical Property:

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Technology Process of [1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-yl]-(4-nitrophenyl)methanone

There total 1 articles about [1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-yl]-(4-nitrophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 145851-04-3
(4-nitrophenyl)(piperidin-4-yl)methanone

: 14625-40-2
2-(chloromethyl)-5-methoxy-1H-benzimidazole

: 1310689-21-4
[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-yl]-(4-nitrophenyl)methanone

Guidance literature:: With sodium carbonate; In acetonitrile; at 45 ℃; for 72h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.03.013

Reference yield:

: 1310689-21-4
[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-yl]-(4-nitrophenyl)methanone

: 1310689-26-9
[1-(5-methoxybenzimidazol)-2-ylmethylpiperidin-4-yl]-(4-⁽¹⁸⁾F-fluorophenyl)methanone

Guidance literature:: With 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride; In dimethyl sulfoxide; at 140 ℃; for 0.25h; Sealed vial;
DOI:10.1016/j.ejmech.2011.03.013

Reference yield:

: 1310689-21-4
[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-yl]-(4-nitrophenyl)methanone

: 1310689-27-0
2-[4-(4-⁽¹⁸⁾F-fluorobenzyl)piperidin-1-yl]methyl-5-methoxybenzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride / dimethyl sulfoxide / 0.25 h / 140 °C / Sealed vial

2: triethylsilane; trifluorormethanesulfonic acid / 0.08 h / 105 °C

With triethylsilane; 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride; trifluorormethanesulfonic acid; In dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.03.013